behavior/neurological
• mice are more sensitive to the acute locomotor activating effects of cocaine and show enhanced reward responses to cocaine
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• injection of kaniate resulted in partial or no seizures in homozygous mice while wild-type mice exhibited severe systemic seizures
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• homozygous mice exhibited impaired associative learning ability compared to wild-type; mice can exhibit learning at higher doses of an aversive stimulus or with more salient flavor stimuli
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growth/size/body
• mutant animals weighed approximately 14% less than littermates
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nervous system
• injection of kaniate resulted in partial or no seizures in homozygous mice while wild-type mice exhibited severe systemic seizures
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• decrease in thickness of several layers was noted
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• reduced in size by approximately 39%
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• neurons from the caudatoputamen of P15 mutant mice exhibited a greater density of dendritic spines than littermates; this increase became undetectable in adult mice
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• alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate responses in striatal neuron are significantly attenuated and are unaffected by Dopamine D1 receptor agonist, SKF 81297
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• hippocampal neurons from homozygous mice exhibited resistance to apoptosis induced by kaniate or by glutamate
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• the amplitude of induced AMPA receptor currents declines much more slowly than in the wild-type
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• high-frequency stimulation of corticostriatal terminals fails to produce long term depression
bathing cells in a dopamine D2 like receptor agonist (quinpirole) restores corticostriatal LTP
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• shown in hippocampal slices derived from the in CA1 region
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homeostasis/metabolism
• hippocampal neurons from homozygous mice exhibited resistance to apoptosis induced by kaniate or by glutamate
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cellular
• hippocampal neurons from homozygous mice exhibited resistance to apoptosis induced by kaniate or by glutamate
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