behavior/neurological
• mice show reduced grip strength (1.13) relative to wild-type controls (1.26)
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• mutants retract paws from thermal stimulus more rapidly than wild-type controls, indicating greater pain sensitivity
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nervous system
• in 2-month old mice, myelin sheaths are significantly thinner in optic nerves compared to wild-type controls
• more axons in sciatic nerve of mutants appear smaller in diameter than in wild-type
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• hypomyelination is observed in hippocampus and cerebral cortex at P15 and P30, but axonal development is normal
• sciatic nerve is hypomyelinated in mutants
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