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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cacnb3tm1Acv
targeted mutation 1, Adolfo Cavalie
MGI:2389248
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cacnb3tm1Acv/Cacnb3tm1Acv involves: 129S1/Sv * 129X1/SvJ MGI:3640603


Genotype
MGI:3640603
hm1
Allelic
Composition
Cacnb3tm1Acv/Cacnb3tm1Acv
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb3tm1Acv mutation (1 available); any Cacnb3 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• homozygotes show a 56% reduction in the L-type calcium channel population of aortic smooth muscle membranes, as shown by dihydropyridine binding studies
• in response to a high salt diet (8% NaCl; 3 months), homozygotes exhibit hypertrophy of the aortic smooth muscle layer
• in response to a high salt diet (8% NaCl; 3 months), homozygotes develop cardiac enlargement
• on a high salt diet (8% NaCl; 3 months), homozygotes exhibit a significantly increased heart weight relative to wild-type mice
• on a normal diet, 12-16-wk-old homozygotes show no significant differences in systolic or diastolic blood pressure relative to wild-type mice
• however, i.p. injection of amlodipine, a DHP analog, fails to reduce systolic and diastolic blood pressure in mutant mice
• on a high salt diet (8% NaCl; 2 weeks), homozygotes (but not wild-type mice) exhibit elevated blood pressure and subsequent hypertrophic changes, in the absence of altered kidney morphology or plasma renin concentrations
• on a high salt diet (8% NaCl; 2 weeks), homozygotes (but not wild-type mice) show increased diastolic blood pressure
• however, i.p. injection of amlodipine fails to cause the expected reduction in diastolic blood pressure
• on a high salt diet (8% NaCl; 2 weeks), homozygotes (but not wild-type mice) show increased systolic blood pressure
• however, i.p. injection of amlodipine fails to cause the expected reduction in systolic blood pressure
• homozygotes display a congenital 30% reduction in Ca2+ channel current density, a slower inactivation rate, and a reduced dihydropyridine (DHP)-sensitive current in aortic smooth muscle cells
• in response to KCl, homozygotes show reduced responsiveness to diltiazem (an L-type calcium channel blocker) in the global [Ca2+]i, with no significant changes in local Ca2+ sparks in mesenteric arteries

muscle
• homozygotes show a 56% reduction in the L-type calcium channel population of aortic smooth muscle membranes, as shown by dihydropyridine binding studies
• in response to a high salt diet (8% NaCl; 3 months), homozygotes exhibit hypertrophy of the aortic smooth muscle layer
• homozygotes display a congenital 30% reduction in Ca2+ channel current density, a slower inactivation rate, and a reduced dihydropyridine (DHP)-sensitive current in aortic smooth muscle cells
• in response to KCl, homozygotes show reduced responsiveness to diltiazem (an L-type calcium channel blocker) in the global [Ca2+]i, with no significant changes in local Ca2+ sparks in mesenteric arteries

immune system
• initial peak and plateau calcium responses are attenuated compared to in wild-type mice
• IL-4 production is reduced

homeostasis/metabolism
• homozygotes display a congenital 30% reduction in Ca2+ channel current density, a slower inactivation rate, and a reduced dihydropyridine (DHP)-sensitive current in aortic smooth muscle cells
• in response to KCl, homozygotes show reduced responsiveness to diltiazem (an L-type calcium channel blocker) in the global [Ca2+]i, with no significant changes in local Ca2+ sparks in mesenteric arteries

hematopoietic system
• initial peak and plateau calcium responses are attenuated compared to in wild-type mice

growth/size/body
• in response to a high salt diet (8% NaCl; 3 months), homozygotes develop cardiac enlargement
• on a high salt diet (8% NaCl; 3 months), homozygotes exhibit a significantly increased heart weight relative to wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory