Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm4Sva
• Allele Name: targeted mutation 4, Alcino Silva
• Allele ID: MGI:2389254
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^tm4Sva/Camk2a^tm4Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764493
hm2	Camk2a^tm4Sva/Camk2a^tm4Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:3764498

Genotype
MGI:3764493

hm1

• Allelic Composition: Camk2a^tm4Sva/Camk2a^tm4Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:127397 )

N • unlike in Camk2a^tm2Sva homozygotes, field excitatory postsynaptic potential and synaptic plasticity are normal

enhanced long-term potentiation ( J:127397 )

• long term potentiation is increased upon weak stimulation (150 theta bursts at 50 Hz)

• however, long term potentiation is normal upon strong stimulation (4 theta bursts at 100 Hz)

Genotype
MGI:3764498

hm2

• Allelic Composition: Camk2a^tm4Sva/Camk2a^tm4Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

behavior/neurological

abnormal contextual conditioning behavior ( J:79714 )

• contextual conditioning is generalized with mice exhibiting increased freezing at the onset of the tone training

abnormal spatial learning ( J:79714 )

• when probed after 14 days of training in a hidden platform Morris maze test, mice spend less time searching in the quadrant containing the platform and cross the position where the platform was less often when compared to wild-type mice

• however, mice probed after 8 days of training perform as well as wild-type mice in a hidden platform Morris water maze test

• spatial reversal learning in mice is impaired

enhanced coordination ( J:79714 )

• mice display enhanced coordination on an accelerating rotarod

seizures ( J:79714 )

• older mice exhibit handling-induced seizures (3% of mice 2 to 4 months old, 30% of mice 7 to 9 months old and 90% of mice 12 to 14 months old)

nervous system

seizures ( J:79714 )

• older mice exhibit handling-induced seizures (3% of mice 2 to 4 months old, 30% of mice 7 to 9 months old and 90% of mice 12 to 14 months old)

abnormal long-term potentiation ( J:79714 )

• when subjected to weak stimuli (4 pulses at 100 Hz) or 10 Hz per 10 second tetanus mice exhibit lowered long term potentitation threshold

• however, long term potentiation is not enhanced and treatment with APV , an NMDA-receptor antagonist, blocks the lowered long term potentiation threshold