Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm3Sva
• Allele Name: targeted mutation 3, Alcino Silva
• Allele ID: MGI:2389262
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^tm3Sva/Camk2a^tm3Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764492
hm2	Camk2a^tm3Sva/Camk2a^tm3Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:3764496

Genotype
MGI:3764492

hm1

• Allelic Composition: Camk2a^tm3Sva/Camk2a^tm3Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle morphology ( J:127397 )

• docked synaptic vesicles are increased in size (24+/-1.3 um compared to 20+/-0.7 um in wild-type mice and 21+/-1.2 um in Camk2a^tm5Sva homozygotes)

abnormal synaptic vesicle number ( J:127397 )

• the number of docked synaptic vesicles is increased 20% (5.6+/-0.5 per active zone compared to 4.6+/-0.2 per active zone in wild-type mice)

abnormal synaptic plasticity ( J:127397 )

• synaptic augmentation is increased and synaptic fatigue is decreased compared to in wild-type mice

abnormal excitatory postsynaptic potential ( J:127397 )

• field excitatory postsynaptic potential is increased

reduced long-term potentiation ( J:127397 )

Genotype
MGI:3764496

hm2

• Allelic Composition: Camk2a^tm3Sva/Camk2a^tm3Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

behavior/neurological

abnormal contextual conditioning behavior ( J:79714 )

• contextual conditioning is severely disrupted

abnormal spatial learning ( J:79714 )

• mice display severely impaired spatial learning in a hidden platform Morris water maze test

• when probed in a hidden platform Morris water maze test, mice do no selectively search for the platform in the target quadrant and continue to do so less selectively than wild-type mice after additional training days

nervous system

reduced long-term potentiation ( J:79714 )

• a strong theta burst (100 Hz for 1 second) induces a modest level of long term potentiation compared to in wild-type mice