All Phenotypes Tg(ARR2/Pbsn-FGF8)3Prb MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1Hwu/Pten⁺ Tg(ARR2/Pbsn-FGF8)3Prb/0 Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2	MGI:4843916
tg2	Tg(ARR2/Pbsn-FGF8)3Prb/0	involves: C57BL/6 * DBA/2	MGI:4838532

Allelic Composition	Pten^tm1Hwu/Pten⁺ Tg(ARR2/Pbsn-FGF8)3Prb/0 Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(ARR2/Pbsn-FGF8)3Prb mutation (1 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:106650 )

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

increased prostate gland adenocarcinoma incidence ( J:106650 )

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:106650 )

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

reproductive system

prostate gland epithelial hyperplasia ( J:106650 )

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

increased prostate gland adenocarcinoma incidence ( J:106650 )

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:106650 )

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

neoplasm

increased prostate gland adenocarcinoma incidence ( J:106650 )

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:106650 )

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

increased metastatic potential ( J:106650 )

• metastasis of adenocarcionma into lymph nodes is observed, with 50-60% penetrance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:106650

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:78918 )

• stromal hypercellularity in the prostate

prostate gland hyperplasia ( J:78918 , J:106650 )

• mice develop prostatic hyperplasia in the lateral and ventral prostates as early as 2-3 months of age and in other lobes between 6 and 16 months of age (J:78918)

• papillary hyperplasia is seen around 16 months of age in ventral, lateral and dorsal prostates but not in the anterior prostate (J:78918)

(J:106650)

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

• dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

• 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

• by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

• mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

prostate gland inflammation ( J:78918 )

• chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

immune system

increased inflammatory response ( J:78918 )

• mild chronic inflammation is seen in the stroma of the ductus deferens, seminal vesicle and epididymis in some males

prostate gland inflammation ( J:78918 )

• chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

reproductive system

abnormal prostate gland morphology ( J:78918 )

• stromal hypercellularity in the prostate

prostate gland hyperplasia ( J:78918 , J:106650 )

• mice develop prostatic hyperplasia in the lateral and ventral prostates as early as 2-3 months of age and in other lobes between 6 and 16 months of age (J:78918)

• papillary hyperplasia is seen around 16 months of age in ventral, lateral and dorsal prostates but not in the anterior prostate (J:78918)

(J:106650)

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

• dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

• 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

• by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

• mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

prostate gland inflammation ( J:78918 )

• chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

• dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

• 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

• by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

• mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

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