All Phenotypes Tg(ARR2/Pbsn-FGF8)3Prb MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1Hwu/Pten⁺ Tg(ARR2/Pbsn-FGF8)3Prb/0 Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2	MGI:4843916
tg2	Tg(ARR2/Pbsn-FGF8)3Prb/0	involves: C57BL/6 * DBA/2	MGI:4838532

Allelic Composition	Pten^tm1Hwu/Pten⁺ Tg(ARR2/Pbsn-FGF8)3Prb/0 Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(ARR2/Pbsn-FGF8)3Prb mutation (1 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:106650 )

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

increased prostate gland adenocarcinoma incidence ( J:106650 )

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:106650 )

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

reproductive system

prostate gland epithelial hyperplasia ( J:106650 )

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

increased prostate gland adenocarcinoma incidence ( J:106650 )

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:106650 )

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

neoplasm

increased prostate gland adenocarcinoma incidence ( J:106650 )

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:106650 )

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

increased metastatic potential ( J:106650 )

• metastasis of adenocarcionma into lymph nodes is observed, with 50-60% penetrance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:106650

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:78918 )

• stromal hypercellularity in the prostate

prostate gland hyperplasia ( J:78918 , J:106650 )

• mice develop prostatic hyperplasia in the lateral and ventral prostates as early as 2-3 months of age and in other lobes between 6 and 16 months of age (J:78918)

• papillary hyperplasia is seen around 16 months of age in ventral, lateral and dorsal prostates but not in the anterior prostate (J:78918)

(J:106650)

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

• dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

• 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

• by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

• mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

prostate gland inflammation ( J:78918 )

• chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

immune system

increased inflammatory response ( J:78918 )

• mild chronic inflammation is seen in the stroma of the ductus deferens, seminal vesicle and epididymis in some males

prostate gland inflammation ( J:78918 )

• chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

reproductive system

abnormal prostate gland morphology ( J:78918 )

• stromal hypercellularity in the prostate

prostate gland hyperplasia ( J:78918 , J:106650 )

• mice develop prostatic hyperplasia in the lateral and ventral prostates as early as 2-3 months of age and in other lobes between 6 and 16 months of age (J:78918)

• papillary hyperplasia is seen around 16 months of age in ventral, lateral and dorsal prostates but not in the anterior prostate (J:78918)

(J:106650)

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

• dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

• 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

• by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

• mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

prostate gland inflammation ( J:78918 )

• chronic inflammation is seen in the prostrate starting at 5 months of age, mostly involving T cells

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:78918 , J:106650 )

• dysplasia, or low-grade prostatic intraepithelial neoplasia is detected beginning at 5-7 months of age (J:78918)

• 100% of males exhibit multifocal epithelial hyperplasia during the first 14 months and 35% have areas of low-grade prostatic intraepithelial neoplasia (J:78918)

• by 15-24 months of age, 66% of mice have low-grade prostatic intraepithelial neoplasia and 51% of mice have high-grade prostatic intraepithelial neoplasia (J:78918)

• mutants display prostate hyperplasia and PIN but do not progress to adenocarcinoma (J:106650)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24