Allele Symbol Allele Name Allele ID |
Smad2tm2Kato targeted mutation 2, Mitsuyasu Kato MGI:2389479 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• a small number of mice die suddenly, before thirty weeks of age, as result of lethal intestinal obstruction by large tumorous polyps
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• numerous intestinal tumors develop in homozygotes: compound mutants have more intestinal tumors >4 mm in diameter than Apctm1Mmt heterozygotes
• frequently one or two tumors >6 mm in diameter develop
• 10-15% of intestinal polyps exhibit stromal and vascular invasion
• tubular adenomas vary in size and shape, and solid colonies of poorly differentiated carcinoma cells are sometimes observed
• nuclei display more hyperchromaticity than those in tumors in Apc single heterozygotes; nuclear atypia in tumors is enhanced indicating increased malignancy
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• numerous intestinal tumors develop in homozygotes: compound mutants have more intestinal tumors >4 mm in diameter than Apctm1Mmt heterozygotes
• frequently one or two tumors >6 mm in diameter develop
• 10-15% of intestinal polyps exhibit stromal and vascular invasion
• tubular adenomas vary in size and shape, and solid colonies of poorly differentiated carcinoma cells are sometimes observed
• nuclei display more hyperchromaticity than those in tumors in Apc single heterozygotes; nuclear atypia in tumors is enhanced indicating increased malignancy
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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