Phenotypes associated with this allele

• Allele Symbol: Tg(Hsp70-1-cre)1Arge
• Allele Name: transgene insertion 1, Argiris Efstratiadis
• Allele ID: MGI:2389571
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA	MGI:3805023
cn2	Brca1^tm1Arge/Brca1^tm1Arge Tg(Hsp70-1-cre)1Arge/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3805031
cn3	Actb^tm2(Tag)Arge/Actb^+ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032629
cn4	Actb^tm1(PyVT)Arge/Actb^+ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032631
cn5	Htt^tm4Szi/Htt^tm5Szi Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3664662
cn6	Htt^tm4Szi/Htt^tm4Szi Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3664663
cn7	Eef1a1^tm1(Kras*)Arge/Eef1a1^+ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3837706
cn8	Hus1^tm1Led/Hus1^tm1Rsw Tg(Hsp70-1-cre)1Arge/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA	MGI:3590177

Genotype
MGI:3805023

cn1

• Allelic Composition: Bard1^tm1Thl/Bard1^tm2Thl; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Genotype
MGI:3805031

cn2

• Allelic Composition: Brca1^tm1Arge/Brca1^tm1Arge; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Genotype
MGI:3032629

cn3

• Allelic Composition: Actb^tm2(Tag)Arge/Actb⁺; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

neoplasm

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

endocrine/exocrine glands

enlarged seminal vesicle ( J:87544 )

♂ • enlarged due to pronounced hyperplasia of smooth muscle layers

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

liver/biliary system

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

muscle

abnormal smooth muscle morphology ( J:87544 )

• smooth muscle hyperproliferation in both males and females

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

reproductive system

enlarged seminal vesicle ( J:87544 )

♂ • enlarged due to pronounced hyperplasia of smooth muscle layers

abnormal uterus morphology ( J:87544 )

♀ • development of leiomyosarcomas in the uterus

growth/size/body

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

Genotype
MGI:3032631

cn4

• Allelic Composition: Actb^{tm1(PyVT)Arge}/Actb⁺; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:87544 )

• death by E6.5

Genotype
MGI:3664662

cn5

• Allelic Composition: Htt^tm4Szi/Htt^tm5Szi; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

abnormal embryonic tissue morphology ( J:111323 )

• embryonic portion of conceptus is small and stubby with no obvious head folds

absent somites ( J:111323 )

• at E8.5

growth/size/body

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

Genotype
MGI:3664663

cn6

• Allelic Composition: Htt^tm4Szi/Htt^tm4Szi; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

abnormal embryonic tissue morphology ( J:111323 )

• embryonic portion of conceptus is small and stubby with no obvious head folds

absent somites ( J:111323 )

• at E8.5

growth/size/body

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

Genotype
MGI:3837706

cn7

• Allelic Composition: Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality ( J:146290 )

Genotype
MGI:3590177

cn8

• Allelic Composition: Hus1^tm1Led/Hus1^tm1Rsw; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA

mortality/aging

prenatal lethality, incomplete penetrance ( J:99339 )

• fewer than expected mutants are found and those that do survive have little or no Cre-mediated recombination in most tissues with the exception of the lung and mammary gland where moderate levels of recombination are seen