Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Vav-BCL2)69Jad transgene insertion 69, Jerry M Adams MGI:2429387 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice
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• diffuse large B cell lymphoma more so than in Tg(Vav-BCL2)1Jad mice
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• more so than in Tg(Vav-BCL2)1Jad mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice
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• diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice
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• more so than in Tg(Vav-BCL2)1Jad mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• GFP+ pre-B cells are absent in the bone marrow
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• GFP+ pre-B cells are absent in the bone marrow
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically
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• increased number of B220- cells, expressing more CD138 when immunized periodically
• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically
• normal mature B cell numbers in bone marrow when immunized periodically
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically
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• increased number of B220- cells, expressing more CD138 when immunized periodically
• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically
• normal mature B cell numbers in bone marrow when immunized periodically
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically
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• when immunized periodically
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• in kidney, lung, liver, intestines and other organs when immunized periodically
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
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• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
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• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increase in splenic B cells over non mutant controls but lower numbers than in animals carrying the transgene alone
• CD93- IgMlow mature B cells are increased 6.5X but CD93+ IgMhigh T1 B cell number is normal
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• levels are about 12% of normal
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• levels are about 12% of normal
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• increase in splenic B cells over non mutant controls but lower numbers than in animals carrying the transgene alone
• CD93- IgMlow mature B cells are increased 6.5X but CD93+ IgMhigh T1 B cell number is normal
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• levels are about 12% of normal
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• levels are about 12% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a significant delay in follicular lymphoma (FL) and high-grade lymphoma development relative to mice carrying the transgene on a wild-type background; all tumors display pathognomonic features of FL and a similar Ki67 proliferative index in spleen
• although mice show a reduced incidence of FL when sacrificed at 250 days, the incidence, grade, tumor burden and PD1+ microenvironment of FL at euthanasia are similar to those in mice carrying the transgene on a wild-type background
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• both unimmunized and SRBC-immunized mice exhibit a lower number of GC B cells in spleen than control mice carrying the transgene on a wild-type background
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• mice exhibit a smaller spontaneous GC formation in spleen than mice carrying the transgene on a wild-type background
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• mice exhibit delayed development of autoimmune glomerulonephritis with a lower number of IgG1+ deposits in the kidney than mice carrying the transgene on a wild-type background
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• both unimmunized and SRBC-immunized mice exhibit a lower number of GC B cells in spleen than control mice carrying the transgene on a wild-type background
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• mice exhibit a smaller spontaneous GC formation in spleen than mice carrying the transgene on a wild-type background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die around 13 months of age
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• in less than 10% of mice
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• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice
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• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found
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• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice
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• 5-fold higher in the spleen at 18 weeks
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• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice
• however, expansion of germinal centers is dependent on CD4 T cell help
• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice
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• at 18 weeks
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• at 18 weeks
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• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis
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• 12% of mice develop plasma cell tumors
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• less than 10% of mice develop lymphoblastic lymphomas
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• in less than 10% of mice
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• less than 10% of mice develop large cell B lymphomas
(J:88565)
• diffuse large B cell lymphoma
(J:228913)
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• at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma
(J:88565)
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• in less than 10% of mice
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• mice develop hypercellular glomeruli that contain amorphous, eosinophilic deposits
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• most capillaries are no longer patent
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• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis
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• Bowman epithelium proliferates to form crescents in the most advanced cases
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• in less than 10% of mice
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• in less than 10% of mice
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• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice
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• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found
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• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice
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• 5-fold higher in the spleen at 18 weeks
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• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice
• however, expansion of germinal centers is dependent on CD4 T cell help
• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice
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• at 18 weeks
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• at 18 weeks
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• most capillaries are no longer patent
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| follicular lymphoma | DOID:0050873 |
OMIM:151430 |
J:88565 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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