Analysis Tools
mortality/aging
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• mice die from lymphoma between 10-20 months of age with a mean around 14-15 months
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neoplasm
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• B cell derived lymphoma develops in mice over 10 months of age
• the lymphoma consists of IgM+ and IgD+ B cells
• 88% of the mice have the spleen as the principle organ involved, with the lymphoma infiltrating and destroying the red pulp
• 25% percent of mice have enlarged thymuses with disruption of the general architecture and extensive replacement of the normal cortex and medulla with lymphoma cells
• disseminated lymphoma occurs in about 19% of mice with involvement of the kidneys, lungs, liver and pancreas
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immune system
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• one 3 week old mouse displayed minor spleen hyperplasia
• at 6 months of age, 3 of 4 mice had spleen hyperplasia with one of these mice having infiltration of the red pulp
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• clonal expansion of B cell lymphomas leads to a dominant or co-dominant V-D-J recombination instead of the diverse V-D-J recombinations observed in control mice
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• myeloid hyperplasia was observed in one 6 month old mouse
• myeloid hyperplasia occurs in 30% of mice by the time they are terminally ill with lymphoma with 6% of these having no lymphoid involvement of other tissues
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• Mac-1+ myeloid cell numbers are significantly increased in older mice with lymphoma
• increases in this cell population are noted in the bone marrow and lymph nodes of mice with lymphoma
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hematopoietic system
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• one 3 week old mouse displayed minor spleen hyperplasia
• at 6 months of age, 3 of 4 mice had spleen hyperplasia with one of these mice having infiltration of the red pulp
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• clonal expansion of B cell lymphomas leads to a dominant or co-dominant V-D-J recombination instead of the diverse V-D-J recombinations observed in control mice
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• myeloid hyperplasia was observed in one 6 month old mouse
• myeloid hyperplasia occurs in 30% of mice by the time they are terminally ill with lymphoma with 6% of these having no lymphoid involvement of other tissues
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• Mac-1+ myeloid cell numbers are significantly increased in older mice with lymphoma
• increases in this cell population are noted in the bone marrow and lymph nodes of mice with lymphoma
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growth/size/body
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• one 3 week old mouse displayed minor spleen hyperplasia
• at 6 months of age, 3 of 4 mice had spleen hyperplasia with one of these mice having infiltration of the red pulp
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