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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gclctm1Dwn
targeted mutation 1, Daniel W Nebert
MGI:2429419
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gclctm1Dwn/Gclctm1Dwn involves: 129P2/OlaHsd * C57BL/6J MGI:3836445
ht2
 		Gclctm1Dwn/Gclc+ involves: 129P2/OlaHsd * C57BL/6J MGI:3836446


Genotype
MGI:3836445
hm1
Allelic
Composition		 Gclctm1Dwn/Gclctm1Dwn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gclctm1Dwn mutation (0 available); any Gclc mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3836446
ht2
Allelic
Composition		 Gclctm1Dwn/Gclc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gclctm1Dwn mutation (0 available); any Gclc mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:66499 )
• hepatic GSH levels are about 20% lower compared to controls
• hepatic ascorbate levels are about 30% higher compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory