All Phenotypes Igk<tm1Dhu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igk^tm1Dhu
targeted mutation 1, Dennis Huszar
MGI:2429510

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igk^tm1Dhu/Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca/0 Tg(TcraS106-1,TcrbS106-1)TS1SWAjca/0	C.Cg-Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(TcraS106-1,TcrbS106-1)TS1SWAjca	MGI:5903780
cx2	Igk^tm1Dhu/Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca/0 Tg(Tcra/Tcrb)1Vbo/0	C.Cg-Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(Tcra/Tcrb)1Vbo	MGI:5903778
cx3	Igk-J^tm2Mwg/Igk^tm1Dhu	involves: 129P2/OlaHsd * 129S7/SvEvBrd	MGI:3717904
cx4	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm2Ust/Iglc1^tm2Ust	involves: 129S7/SvEvBrd	MGI:3719676
cx5	Igk-J^tm1Mwg/Igk^tm1Dhu	involves: 129S7/SvEvBrd * C57BL/6	MGI:3717905
cx6	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1Ust/Iglc1⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3719658
cx7	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1Ust/Iglc1^tm1Ust	involves: 129S7/SvEvBrd * C57BL/6	MGI:3719654
cx8	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1.1Ust/Iglc1^tm1.1Ust	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3719655
cx9	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1.1Ust/Iglc1⁺	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3719657
cx10	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm2Ust/Iglc1^tm2Ust	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2657249
cx11	Igh-J^tm1Dhu/Igh-J^{tm1(VDJ-17.2.25)Wabl} Igk^tm1Dhu/Igk^tm1Dhu	Not Specified	MGI:3045805

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca/0 Tg(TcraS106-1,TcrbS106-1)TS1SWAjca/0
Genetic Background	C.Cg-Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(TcraS106-1,TcrbS106-1)TS1SWAjca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)
Tg(H2-Ea-HA)HACIIAjca mutation (1 available)
Tg(TcraS106-1,TcrbS106-1)TS1SWAjca mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent B cells ( J:209872 )

abnormal CD4-positive, alpha beta T cell morphology ( J:209872 )

• decrease in the percentages of IL-17- and IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T cells in the joint-draining lymph nodes of nonarthritic mice

• in mice that develop arthritis despite absence of B cells, the frequencies of IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T are reduced relative to arthritic double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice, but the frequencies of IL-17-secreting Valpha8.3+VBeta10+CD4+ T cells are not

• nonarthritic mice show lower frequencies of clonotypic, but not of total, IFN-gamma-, and IL-17 producing CD4+ T cells than nonarthritic double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

increased CD4-positive, alpha-beta T cell number ( J:209872 )

• percentage of CD4+ T cells is increased, however the number of CD4+ T cells expressing the Vslpha8.3+Vbeta10+ clonotypic TCR does not differ from double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

abnormal spleen morphology ( J:209872 )

• decrease in the overall cellularity of spleens

immune system

absent B cells ( J:209872 )

abnormal CD4-positive, alpha beta T cell morphology ( J:209872 )

• decrease in the percentages of IL-17- and IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T cells in the joint-draining lymph nodes of nonarthritic mice

increased CD4-positive, alpha-beta T cell number ( J:209872 )

abnormal spleen morphology ( J:209872 )

• decrease in the overall cellularity of spleens

abnormal lymph node morphology ( J:209872 )

• decrease in the overall cellularity of the joint-draining lymph nodes

decreased susceptibility to autoimmune disorder ( J:209872 )

• mice exhibit decreased arthritis development compared to double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca/0 Tg(Tcra/Tcrb)1Vbo/0
Genetic Background	C.Cg-Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(Tcra/Tcrb)1Vbo

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

autoimmune arthritis ( J:209872 )

• mice develop arthritis more quickly but with disease penetrance and severity similar to double Tg(Tcra/Tcrb)1Vbo/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

skeleton

autoimmune arthritis ( J:209872 )

• mice develop arthritis more quickly but with disease penetrance and severity similar to double Tg(Tcra/Tcrb)1Vbo/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

Allelic Composition	Igk-J^tm2Mwg/Igk^tm1Dhu
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-J^tm2Mwg mutation (7 available); any Igk-J mutation (11 available)
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:76116 )

N	• IgM density at the pre-B and immature B cell stages is indistinguishable from wild-type mice

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm2Ust/Iglc1^tm2Ust
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1^tm2Ust mutation (0 available); any Iglc1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B-1a cell number ( J:113218 )

• B-1a B cell numbers are increased relative to in Igk^tm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igk^tm1Dhu homozygotes and 18.5% in Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• the ratio of B1 to B2 cells is increased relative to Igk^tm1Dhu homozygotes

hematopoietic system

increased B-1a cell number ( J:113218 )

• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igk^tm1Dhu homozygotes and 18.5% in Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• the ratio of B1 to B2 cells is increased relative to Igk^tm1Dhu homozygotes

Allelic Composition	Igk-J^tm1Mwg/Igk^tm1Dhu
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-J^tm1Mwg mutation (1 available); any Igk-J mutation (11 available)
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:76116 )

N	• IgM density at the pre-B and immature B cell stages is indistinguishable from wild-type mice

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1Ust/Iglc1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1^tm1Ust mutation (0 available); any Iglc1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:68144 )

• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

hematopoietic system

abnormal B cell differentiation ( J:68144 )

• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1Ust/Iglc1^tm1Ust
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

• the ratios of lambda1 to lambda2/3 B cells in the bone marrow and spleen is increased to 14.9 and 11.9, respectively, from 1.5 and 1.1 in wild-type mice

• lambda1 B cells percentages are increased to 82% compared to 54% in wild-type mice

hematopoietic system

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

• the ratios of lambda1 to lambda2/3 B cells in the bone marrow and spleen is increased to 14.9 and 11.9, respectively, from 1.5 and 1.1 in wild-type mice

• lambda1 B cells percentages are increased to 82% compared to 54% in wild-type mice

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1.1Ust/Iglc1^tm1.1Ust
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1^tm1.1Ust mutation (0 available); any Iglc1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:68144 )

• lambda1 B cell numbers are reduced to 15.8% from 92.2% in Igl-C1^tm1Ust/ Igl-C1^tm1Ust Igk^tm1Dhu/ Igk^tm1Dhu mice

• lambda1 B cell numbers are lower than in wild-type mice (15.8% compared with 52.5% in wild-type mice)

hematopoietic system

decreased B cell number ( J:68144 )

• lambda1 B cell numbers are reduced to 15.8% from 92.2% in Igl-C1^tm1Ust/ Igl-C1^tm1Ust Igk^tm1Dhu/ Igk^tm1Dhu mice

• lambda1 B cell numbers are lower than in wild-type mice (15.8% compared with 52.5% in wild-type mice)

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1.1Ust/Iglc1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:68144 )

• lambda1 B cells numbers are reduced to 38.8% from 63.6% in Igl-C1^tm1Ust/ Igl-C1⁺ Igk^tm1Dhu/ Igk^tm1Dhu mice

hematopoietic system

decreased B cell number ( J:68144 )

• lambda1 B cells numbers are reduced to 38.8% from 63.6% in Igl-C1^tm1Ust/ Igl-C1⁺ Igk^tm1Dhu/ Igk^tm1Dhu mice

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm2Ust/Iglc1^tm2Ust
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:74717 )

• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective

decreased immature B cell number ( J:74717 )

• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow

decreased transitional stage T1 B cell number ( J:74717 )

• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells

decreased transitional stage T2 B cell number ( J:74717 )

• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells

decreased B cell number ( J:74717 )

• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen

decreased mature B cell number ( J:74717 )

• 6-fold decrease in the number of mature lamda 1 B cells

• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold

decreased marginal zone B cell number ( J:74717 )

• decrease in marginal zone lamda 1 B cells

hematopoietic system

abnormal B cell differentiation ( J:74717 )

• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective

decreased immature B cell number ( J:74717 )

• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow

decreased transitional stage T1 B cell number ( J:74717 )

• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells

decreased transitional stage T2 B cell number ( J:74717 )

• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells

decreased B cell number ( J:74717 )

• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen

decreased mature B cell number ( J:74717 )

• 6-fold decrease in the number of mature lamda 1 B cells

• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold

decreased marginal zone B cell number ( J:74717 )

• decrease in marginal zone lamda 1 B cells

Allelic Composition	Igh-J^tm1Dhu/Igh-J^{tm1(VDJ-17.2.25)Wabl} Igk^tm1Dhu/Igk^tm1Dhu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Dhu mutation (1 available); any Igh-J mutation (13 available)
Igh-J^{tm1(VDJ-17.2.25)Wabl} mutation (0 available); any Igh-J mutation (13 available)
Igk^tm1Dhu mutation (1 available); any Igk mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:33628 )

• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2

abnormal immature B cell morphology ( J:89757 )

• 80% of bone marrow B cells have an immature phenotype

• rapid turnover

immune system

abnormal B cell differentiation ( J:33628 )

• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2

abnormal immature B cell morphology ( J:89757 )

• 80% of bone marrow B cells have an immature phenotype

• rapid turnover

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