Phenotypes associated with this allele

• Allele Symbol: Tln1^tm3Crit
• Allele Name: targeted mutation 3, David R Critchley
• Allele ID: MGI:2429596
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tln1^tm3Crit/Tln1^tm3Crit	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:3774746

Genotype
MGI:3774746

hm1

• Allelic Composition: Tln1^tm3Crit/Tln1^tm3Crit
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65873 )

• mice die between E8.5 and E9.5

embryo

abnormal embryo development ( J:65873 )

• embryos possess fewer cells than wild-type embryos

• however, apoptosis and cell cycle progression are normal at E7.5

abnormal ectoderm development ( J:65873 )

• at E6.5, the ectoderm is not thinned to a uniform columnar epithelial layer

embryonic growth arrest ( J:65873 )

• at E7.5

decreased embryo size ( J:65873 )

• at E6.5 and E7.5

abnormal extraembryonic tissue morphology ( J:65873 )

• at E7.5, the extraembryonic tissue is reduced compared to in wild-type mice

abnormal trophoblast layer morphology ( J:65873 )

• trophoblast cells cultured on fibronectin and laminin exhibit reduced spreading compared to wild-type cells

abnormal proamniotic cavity morphology ( J:65873 )

• at E7.5, the amniotic cavity fails to divide

small proamniotic cavity ( J:65873 )

• at E6.5, the pro-amniotic cavity is reduced in size

growth/size/body

decreased embryo size ( J:65873 )

• at E6.5 and E7.5