Phenotypes associated with this allele

• Allele Symbol: Ly6e^tm1Zmt
• Allele Name: targeted mutation 1, David J Zammitt
• Allele ID: MGI:2429638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ly6e^tm1Zmt/Ly6e^tm1Zmt	involves: 129S1/Sv	MGI:3581026

Genotype
MGI:3581026

hm1

• Allelic Composition: Ly6e^tm1Zmt/Ly6e^tm1Zmt
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:73972 )

• embryos viable through E14

• by E14.5 embryos pale and smaller than controls

• all necrotic and undergoing resorption by E16

cardiovascular system

dilated heart atrium ( J:73972 )

• significantly enlarged

enlarged heart ( J:73972 )

• hearts normal between E12.5 and E14.5

• ventricles enlarged at E14.5

abnormal heart ventricle morphology ( J:73972 )

• ventricular trabeculation defects

• ruptured ventricles frequent at E14.5-E15.5

abnormal interventricular septum morphology ( J:73972 )

• often fails to close by E14

dilated cardiomyopathy ( J:73972 )

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:73972 )

• disorganized cellular structure of adrenal cortex

failure of adrenal epinephrine secretion ( J:73972 )

• virtually no detectable adrenalin

homeostasis/metabolism

decreased noradrenaline level ( J:73972 )

• noradrenaline levels reduced 50% in adrenals but more or less normal throughout the body

muscle

dilated cardiomyopathy ( J:73972 )

growth/size/body

enlarged heart ( J:73972 )

• hearts normal between E12.5 and E14.5

• ventricles enlarged at E14.5