All Phenotypes Cp<tm1Yos> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cp^tm1Yos
targeted mutation 1, Kunihiro Yoshida
MGI:2429641

Summary

2 genotypes

Allelic Composition	Cp^tm1Yos/Cp^tm1Yos
Genetic Background	C.129P2-Cp^tm1Yos

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cp^tm1Yos mutation (0 available); any Cp mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:142713 )

• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks

• elevated levels of the lipid peroxidation product acrolein in hippocampal neuron cytoplasm

• ubiquitin levels elevated as well

behavior/neurological

abnormal locomotor activation ( J:142713 )

• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks

• reduced activity

abnormal gait ( J:142713 )

• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks

• tendency to stagger

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
aceruloplasminemia		DOID:0050711	OMIM:604290	J:142713

Allelic Composition	Cp^tm1Yos/Cp^tm1Yos
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cp^tm1Yos mutation (0 available); any Cp mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating iron level ( J:79916 )

increased liver iron level ( J:79916 )

• iron deposits in the liver elevated 3.4 fold

• iron deposits in the cytoplasm of both hepatocytes and Kupffer cells

• in periportal areas and around the central veins

liver/biliary system

abnormal Kupffer cell morphology ( J:79916 )