Phenotypes associated with this allele

• Allele Symbol: Cd200^tm1Jods
• Allele Name: targeted mutation 1, Jonathon D Sedgwick
• Allele ID: MGI:2429651
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd200^tm1Jods/Cd200^tm1Jods	C57BL/6-Cd200^tm1Jods	MGI:3576859
hm2	Cd200^tm1Jods/Cd200^tm1Jods	C57BL/6-Cd200^tm1Jods/H	MGI:7334746

Genotype
MGI:3576859

hm1

• Allelic Composition: Cd200^tm1Jods/Cd200^tm1Jods
• Genetic Background: C57BL/6-Cd200^tm1Jods

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased macrophage cell number ( J:65982 , J:79906 )

• increased numbers of CD11b cells in spleen (J:65982)

• all macrophage lineages increased (J:65982)

• 30% increase in resident retinal macrophage (J:79906)

abnormal microglial cell morphology ( J:65982 )

• features of cell suggest activation

abnormal immune system organ morphology ( J:65982 )

increased spleen red pulp amount ( J:65982 )

• enlarged

abnormal lymph node morphology ( J:65982 )

• changed from spherical to tubular formation

enlarged lymph nodes ( J:65982 )

• slightly, especially in the mesenteries

abnormal immune system physiology ( J:65982 )

abnormal macrophage physiology ( J:65982 )

• marginal zone macrophages of the spleen are activated

• lymph node macrophages are activated

abnormal microglial cell physiology ( J:65982 )

• form aggregates normally associated with inflammation or neurodegeneration

• accelerated response to nerve damage (facial nerve transection)

abnormal cytokine level ( J:95862 )

• Th2 associated cytokines are increased in response to "recall" antigens

increased susceptibility to experimental autoimmune encephalomyelitis ( J:65982 )

• accelerated development of experimental autoimmune encephalitis

increased susceptibility to experimental autoimmune uveoretinitis ( J:79906 )

• accelerated development of experimental autoimmune uveoretinitis

increased susceptibility to induced arthritis ( J:65982 )

• increased susceptibility to collagen induced arthritis

nervous system

abnormal microglial cell morphology ( J:65982 )

• features of cell suggest activation

abnormal microglial cell physiology ( J:65982 )

• form aggregates normally associated with inflammation or neurodegeneration

• accelerated response to nerve damage (facial nerve transection)

cellular

increased apoptosis ( J:79906 )

• in "non-T cells" and macrophage

hematopoietic system

increased macrophage cell number ( J:65982 , J:79906 )

• increased numbers of CD11b cells in spleen (J:65982)

• all macrophage lineages increased (J:65982)

• 30% increase in resident retinal macrophage (J:79906)

abnormal microglial cell morphology ( J:65982 )

• features of cell suggest activation

increased spleen red pulp amount ( J:65982 )

• enlarged

abnormal macrophage physiology ( J:65982 )

• marginal zone macrophages of the spleen are activated

• lymph node macrophages are activated

abnormal microglial cell physiology ( J:65982 )

• form aggregates normally associated with inflammation or neurodegeneration

• accelerated response to nerve damage (facial nerve transection)

skeleton

increased susceptibility to induced arthritis ( J:65982 )

• increased susceptibility to collagen induced arthritis

homeostasis/metabolism

abnormal cytokine level ( J:95862 )

• Th2 associated cytokines are increased in response to "recall" antigens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autoimmune disease		DOID:417	OMIM:109100	J:65982

Genotype
MGI:7334746

hm2

• Allelic Composition: Cd200^tm1Jods/Cd200^tm1Jods
• Genetic Background: C57BL/6-Cd200^tm1Jods/H

behavior/neurological

behavior/neurological phenotype ( J:326965 )

N • mice exhibit normal recovery from carrageenan-induced inflammatory hyperalgesia