Phenotypes associated with this allele

• Allele Symbol: Cabin1^tm1.1Che
• Allele Name: targeted mutation 1.1, Jianzhu Chen
• Allele ID: MGI:2429675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cabin1^tm1.1Che/Cabin1^tm1.1Che	involves: 129S4/SvJae * BALB/c	MGI:3778026

Genotype
MGI:3778026

hm1

• Allelic Composition: Cabin1^tm1.1Che/Cabin1^tm1.1Che
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:72760 )

N • B and T cell development, total numbers, ratios of subpopulations and levels of thymocyte apoptosis are similar to wild-type

abnormal humoral immune response ( J:72760 )

• when mice are immunized with T cell dependent antigen NP-KLH, levels of NP-specific IgG1 and IgG2b, are significantly higher than in immunized wild-type

increased IgE level ( J:72760 )

• levels are increased (6x) compared to wild-type mice

increased IgG1 level ( J:72760 )

• levels are increased (3x) compared to wild-type mice

increased IgG2b level ( J:72760 )

• levels are increased (2x) compared to wild-type mice

abnormal cytokine secretion ( J:72760 )

• cultured CD4 T cells secrete higher levels of Il2 and Ifng in response to anti-CD3 than wild-type cells

hematopoietic system

increased IgE level ( J:72760 )

• levels are increased (6x) compared to wild-type mice

increased IgG1 level ( J:72760 )

• levels are increased (3x) compared to wild-type mice

increased IgG2b level ( J:72760 )

• levels are increased (2x) compared to wild-type mice