All Phenotypes Kcnq1ot1<tm1.1Mjh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcnq1ot1^tm1.1Mjh
targeted mutation 1.1, Michael J Higgins
MGI:2429679

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺	involves: 129S4/SvJae * C57BL/6J * FVB/N	MGI:2451332
cx2	Kcnq1ot1^tm1.1Mjh/Del(7Ins2-Tel)1Lef	involves: 129 * C57BL/6 * ICR	MGI:3772940
cx3	Ascl2^tm1Alj/Ascl2⁺ Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺	involves: 129 * C57BL/6 * ICR	MGI:3772941

Allelic Composition	Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased embryo size ( J:79882 )

• beginning at E14.5, mice carrying a paternally-inherited allele are smaller than wild-type mice

decreased body weight ( J:79882 )

• mice carrying a paternally-inherited allele weigh 20%-25% less than wild-type littermates up to 6 weeks of age

• weight so internal organs (kidney, liver and lung) are decreased proportional to weight reduction

embryo

decreased embryo size ( J:79882 )

• beginning at E14.5, mice carrying a paternally-inherited allele are smaller than wild-type mice

liver/biliary system

decreased liver weight ( J:79882 )

• in mice carrying a paternally-inherited allele

renal/urinary system

decreased kidney weight ( J:79882 )

• in mice carrying a paternally-inherited allele

respiratory system

decreased lung weight ( J:79882 )

• in mice carrying a paternally-inherited allele

cellular

maternal imprinting ( J:79882 )

• mice do not exhibit defects when the allele is inherited maternally

Allelic Composition	Kcnq1ot1^tm1.1Mjh/Del(7Ins2-Tel)1Lef
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:130399 )

N	• no embryonic lethality is observed in mice maternally inheriting the chromosome deletion

cellular

abnormal imprinting ( J:130399 )

• embryonic lethality associated with maternal transmission of the chromosome deletion is prevented by the addition of the targeted mutation due to a lack of paternal imprinting of genes in the distal portion of chromosome 7

Allelic Composition	Ascl2^tm1Alj/Ascl2⁺ Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2^tm1Alj mutation (0 available); any Ascl2 mutation (15 available)
Kcnq1ot1^tm1.1Mjh mutation (0 available); any Kcnq1ot1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:130399 )

N	• no embryonic lethality is observed in mice maternally inheriting the Ascl2^tm1Alj allele

cellular

abnormal imprinting ( J:130399 )

• embryonic lethality associated with maternal transmission of Ascl2^tm1Alj allele is prevented by the addition of the Kcnq1^tm1.1Mjh allele due to a lack of paternal imprinting of genes in the distal portion of chromosome 7

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