All Phenotypes Tg(Nes-cre)1Wmz MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0	involves: 129 * C57BL/6 * FVB/N * SJL/J	MGI:5431138
cn2	Kdr^tm1Jrt/Kdr^tm2Sato Tg(Nes-cre)1Wmz/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5432161
cn3	Itgb8^tm1Lfr/Itgb8^tm2Lfr Tg(Nes-cre)1Wmz/0	involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3609117
cn4	Numb^tm1Ynj/Numb^tm1Ynj Numbl^tm1Wmz/Numbl^tm1Wmz Tg(Nes-cre)1Wmz/0	involves: 129X1/SvJ	MGI:2451225
cn5	Numb^tm1Ynj/Numb^tm1Ynj Tg(Nes-cre)1Wmz/0	involves: 129X1/SvJ	MGI:2451227
cn6	Insc^tm1Jakn/Insc^tm1Jakn Tg(Nes-cre)1Wmz/0	involves: C57BL/6	MGI:5304353
cn7	Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn}/Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn} Tg(Nes-cre)1Wmz/0	involves: C57BL/6	MGI:5304355
cn8	Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir21)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0	involves: C57BL/6 * C57BL/6J * SJL/J	MGI:4830769

Allelic Composition	Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0 mice develop disseminated lymphoma

growth/size/body

enlarged liver ( J:185598 )

• in some mice reared without doxycycline

enlarged spleen ( J:185598 )

• by 5 months in mice reared without doxycycline

increased spleen weight ( J:185598 )

• 10 times in mice reared without doxycycline

mortality/aging

premature death ( J:185598 )

• mice reared without doxycycline die between 3 and 5 months

• however, doxycycline treatment rescues phenotype

immune system

abnormal immune system morphology ( J:185598 )

• mice reared without doxycycline develop lymphoid pathology as early as 2 weeks of age

thymus hyperplasia ( J:185598 )

• in mice reared without doxycycline

enlarged spleen ( J:185598 )

• by 5 months in mice reared without doxycycline

increased spleen weight ( J:185598 )

• 10 times in mice reared without doxycycline

increased spleen white pulp amount ( J:185598 )

• in mice reared without doxycycline

enlarged lymph nodes ( J:185598 )

• by 5 months in mice reared without doxycycline

behavior/neurological

ataxia ( J:185598 )

• occasionally in mice reared without doxycycline

hunched posture ( J:185598 )

• in mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

hindlimb paresis ( J:185598 )

• severe hind limb paresis in some mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

neoplasm

tumor regression ( J:185598 )

• following treatment with doxycycline partially due to apoptosis in mice reared without doxycycline

increased B cell derived lymphoma incidence ( J:185598 )

• in most mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

integument

abnormal coat appearance ( J:185598 )

• scruffy in mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

liver/biliary system

enlarged liver ( J:185598 )

• in some mice reared without doxycycline

nervous system

nervous system phenotype ( J:185598 )

N	• doxycycline-treated mice exhibit normal brain morphology

respiratory system

respiratory distress ( J:185598 )

• by 5 months in mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

cellular

increased apoptosis ( J:185598 )

• tumor cells from mice reared without doxycycline exhibit increased apoptosis following doxycycline treatment

hematopoietic system

thymus hyperplasia ( J:185598 )

• in mice reared without doxycycline

enlarged spleen ( J:185598 )

• by 5 months in mice reared without doxycycline

increased spleen weight ( J:185598 )

• 10 times in mice reared without doxycycline

increased spleen white pulp amount ( J:185598 )

• in mice reared without doxycycline

endocrine/exocrine glands

thymus hyperplasia ( J:185598 )

• in mice reared without doxycycline

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoma		DOID:0060058		J:185598

Allelic Composition	Kdr^tm1Jrt/Kdr^tm2Sato Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Kdr^tm2Sato mutation (1 available); any Kdr mutation (74 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:175836 )

N	• normal numbers of gonadotropin-releasing hormone neurons

Allelic Composition	Itgb8^tm1Lfr/Itgb8^tm2Lfr Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8^tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8^tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

intracranial hemorrhage ( J:102190 )

• hemorrhaging is similar to mutants crossed to Tg(Nes-cre)1Kln and less severe than in mice homozygous for Itgb8^tm1Lfr

nervous system

intracranial hemorrhage ( J:102190 )

• hemorrhaging is similar to mutants crossed to Tg(Nes-cre)1Kln and less severe than in mice homozygous for Itgb8^tm1Lfr

Allelic Composition	Numb^tm1Ynj/Numb^tm1Ynj Numbl^tm1Wmz/Numbl^tm1Wmz Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Numbl^tm1Wmz mutation (0 available); any Numbl mutation (32 available)
Numb^tm1Ynj mutation (0 available); any Numb mutation (59 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79917 )

• embyros die around E12.5

growth/size/body

decreased embryo size ( J:79917 )

• embryos are 80%-90% the size of wild-type littermates

nervous system

abnormal neural tube morphology ( J:79917 )

• thinned neural tube from the most rostral telencephalon to caudal spinal cord, including optic discs

abnormal embryonic neuroepithelium morphology ( J:79917 )

• frequent buckling of the surface

decreased embryonic neuroepithelium thickness ( J:79917 )

• the neuroepithelium is only one-quarter to one-half the thickness of that in control littermates

decreased neuronal precursor cell number ( J:79917 )

• severe neural progenitor cell loss

embryo

decreased embryo size ( J:79917 )

• embryos are 80%-90% the size of wild-type littermates

abnormal neural tube morphology ( J:79917 )

• thinned neural tube from the most rostral telencephalon to caudal spinal cord, including optic discs

abnormal embryonic neuroepithelium morphology ( J:79917 )

• frequent buckling of the surface

decreased embryonic neuroepithelium thickness ( J:79917 )

• the neuroepithelium is only one-quarter to one-half the thickness of that in control littermates

Allelic Composition	Numb^tm1Ynj/Numb^tm1Ynj Tg(Nes-cre)1Wmz/0
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Numb^tm1Ynj mutation (0 available); any Numb mutation (59 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:79917 )

Allelic Composition	Insc^tm1Jakn/Insc^tm1Jakn Tg(Nes-cre)1Wmz/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insc^tm1Jakn mutation (0 available); any Insc mutation (30 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:178712 )

• in the ventricular zone the number of basally located mitotic cells is strongly reduced at E14.5

abnormal brain development ( J:178712 )

abnormal cortical intermediate zone morphology ( J:178712 )

• thickness is reduced by about 25%

thin cortical plate ( J:178712 )

• thickness is reduced by about 40%

decreased brain size ( J:178712 )

• at E14.5

enlarged lateral ventricles ( J:178712 )

• at E14.5

abnormal cerebral cortex morphology ( J:178712 )

abnormal stratification in cerebral cortex ( J:178712 )

• fewer cells are present in layers II-IV

thin cerebral cortex ( J:178712 )

• cortical thickness is reduced by around 20% both medially and laterally

abnormal lateral ganglionic eminence morphology ( J:178712 )

• at E14.5 the protrusion of the lateral ganglionic eminence into the ventricles is reduced

abnormal neuron morphology ( J:178712 )

• the size of neurons in the cortical intermediate zone and cortical plate is reduced

decreased neuron number ( J:178712 )

• at E14.5 the number of cortical plate neurons is reduced by almost half

cellular

abnormal neuronal precursor proliferation ( J:178712 )

• in the ventricular zone the number of basally located mitotic cells is strongly reduced at E14.5

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn}/Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn} Tg(Nes-cre)1Wmz/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Nes-cre)1Wmz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

seizures ( J:178712 )

• frequently show epileptic crisis

abnormal neuronal precursor proliferation ( J:178712 )

• vertical spindle reorientation leads to the frequent generation of progenitor cells located outside the ventricular zone

• in the ventricular zone the number of basally located mitotic cells is increased at E14.5

abnormal brain development ( J:178712 )

abnormal cortical intermediate zone morphology ( J:178712 )

• up to 3 times thicker than in controls

abnormal cortical plate morphology ( J:178712 )

• up to 3 times thicker than in controls

abnormal cerebral cortex morphology ( J:178712 )

abnormal stratification in cerebral cortex ( J:178712 )

• more cells are present in layers II-IV

• layer IV is barely recognizable and appears to be fused with layer V

thickened cerebral cortex ( J:178712 )

• cortical thickness is increased by around 20% in the medial region and by about 40% in the central and lateral regions

abnormal neuron morphology ( J:178712 )

• the size of neurons in the cortical intermediate zone and cortical plate is increased

abnormal radial glial cell morphology ( J:178712 )

• at E13.5 the fraction of oblique and vertical divisions of mitotic spindles in radial glial cells is significantly increased

• alterations in the radial organization of the radial glial cell fibers

increased neuron number ( J:178712 )

• at E14.5 the number of cortical plate neurons is significantly increased

cellular

abnormal radial glial cell morphology ( J:178712 )

• at E13.5 the fraction of oblique and vertical divisions of mitotic spindles in radial glial cells is significantly increased

• alterations in the radial organization of the radial glial cell fibers

abnormal neuronal precursor proliferation ( J:178712 )

• vertical spindle reorientation leads to the frequent generation of progenitor cells located outside the ventricular zone

• in the ventricular zone the number of basally located mitotic cells is increased at E14.5

behavior/neurological

seizures ( J:178712 )

• frequently show epileptic crisis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged spleen ( J:163919 )

• 8-fold in severe cases after doxycycline withdrawal

mortality/aging

premature death ( J:163919 )

• mice not fed doxycycline exhibit die before 3 months of age unlike wild-type mice

• however, mice fed doxycycline are alive at 3 months of age

immune system

abnormal thymus morphology ( J:163919 )

• after doxycycline withdrawal, thymus structure is altered by invasion of neoplastic cells unlike in similarly treated wild-type mice

abnormal thymus corticomedullary boundary morphology ( J:163919 )

• after doxycycline withdrawal

enlarged thymus ( J:163919 )

• 20-fold in severe cases after doxycycline withdrawal

decreased leukocyte cell number ( J:163919 )

• in 4 of 7 mice at 3 months

abnormal spleen morphology ( J:163919 )

• after doxycycline withdrawal, spleen abnormalities are due to malignant invasion of red pulp unlike in similarly treated wild-type mice

enlarged spleen ( J:163919 )

• 8-fold in severe cases after doxycycline withdrawal

intermingled spleen red and white pulp ( J:163919 )

• after doxycycline withdrawal

enlarged lymph nodes ( J:163919 )

• two months after doxycycline withdrawal and in mice not fed doxycycline

neoplasm

abnormal tumor morphology ( J:163919 )

• mice fed doxycycline after a period of not consuming it exhibit regression of lymphomas associated with increased apoptosis of tumor cells and decreased cell proliferation compared with untreated mice

increased tumor incidence ( J:163919 )

• after doxycycline withdrawal, mice exhibit malignant invasion in the spleen, thymus, peripheral blood, and other organs, especially the liver and less frequently the kidney, unlike in similarly treated wild-type mice

• however, mice fed doxycycline exhibit remission of tumors and tumor-associated pathologies

increased lymphoma incidence ( J:163919 )

• mice not fed doxycycline exhibit external signs of lymphoma (lymphadenopathy and/or paresis of rear limbs) unlike wild-type mice

• however, mice fed doxycycline do not exhibit pathologies associated with lymphomas

behavior/neurological

hunched posture ( J:163919 )

• two months after doxycycline withdrawal

hindlimb paresis ( J:163919 )

• paresis in the hindlimbs two months after doxycycline withdrawal

skeleton

abnormal bone marrow morphology ( J:163919 )

• after doxycycline withdrawal, mice exhibit extended bone marrow in the thoracic and lumbar vertebrae, femur, sternum, and hard palate causing paresis, bone fractures, and invasion of surrounding tissue unlike similarly treated wild-type mice

respiratory system

respiratory distress ( J:163919 )

• two months after doxycycline withdrawal

hematopoietic system

abnormal thymus morphology ( J:163919 )

• after doxycycline withdrawal, thymus structure is altered by invasion of neoplastic cells unlike in similarly treated wild-type mice

abnormal thymus corticomedullary boundary morphology ( J:163919 )

• after doxycycline withdrawal

enlarged thymus ( J:163919 )

• 20-fold in severe cases after doxycycline withdrawal

anemia ( J:163919 )

• at 3 months

• however, mice treated with doxycyline do not exhibit anemia

decreased erythrocyte cell number ( J:163919 )

• at 3 months

decreased hemoglobin content ( J:163919 )

• at 3 months

decreased leukocyte cell number ( J:163919 )

• in 4 of 7 mice at 3 months

abnormal spleen morphology ( J:163919 )

• after doxycycline withdrawal, spleen abnormalities are due to malignant invasion of red pulp unlike in similarly treated wild-type mice

enlarged spleen ( J:163919 )

• 8-fold in severe cases after doxycycline withdrawal

intermingled spleen red and white pulp ( J:163919 )

• after doxycycline withdrawal

integument

ruffled hair ( J:163919 )

• two months after doxycycline withdrawal

endocrine/exocrine glands

abnormal thymus morphology ( J:163919 )

• after doxycycline withdrawal, thymus structure is altered by invasion of neoplastic cells unlike in similarly treated wild-type mice

abnormal thymus corticomedullary boundary morphology ( J:163919 )

• after doxycycline withdrawal

enlarged thymus ( J:163919 )

• 20-fold in severe cases after doxycycline withdrawal

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