Phenotypes associated with this allele

• Allele Symbol: Asic3^tm1Wsh
• Allele Name: targeted mutation 1, Michael J Welsh
• Allele ID: MGI:2429689
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asic3^tm1Wsh/Asic3^tm1Wsh	B6.129-Asic3^tm1Wsh	MGI:4418090
hm2	Asic3^tm1Wsh/Asic3^tm1Wsh	involves: 129S1/Sv * 129X1/SvJ	MGI:4354586
hm3	Asic3^tm1Wsh/Asic3^tm1Wsh	involves: 129S1/Sv * 129X1/SvJ * C57BL	MGI:2446649

Genotype
MGI:4418090

hm1

• Allelic Composition: Asic3^tm1Wsh/Asic3^tm1Wsh
• Genetic Background: B6.129-Asic3^tm1Wsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:128319 )

• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:128319 )

• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice

Genotype
MGI:4354586

hm2

• Allelic Composition: Asic3^tm1Wsh/Asic3^tm1Wsh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

hyporesponsive to tactile stimuli ( J:119060 )

• following a second injection of pH 4 saline 5 days after the first injection, mice fail to exhibit induction of mechanical hyperalgesia unlike wild-type mice

• after a second pH 4 saline, spinal wide dynamic range (WDR) neuron response fail exhibit expansion of the receptive to tactile stimuli unlike wild-type neurons

nervous system

abnormal nervous system electrophysiology ( J:119060 )

• following a second injection of pH 4 saline 5 days after the first injection, mice fail to exhibit induction of mechanical hyperalgesia unlike wild-type mice

• after a second pH 4 saline, spinal wide dynamic range (WDR) neuron response fail exhibit expansion of the receptive to tactile stimuli unlike wild-type neurons

Genotype
MGI:2446649

hm3

• Allelic Composition: Asic3^tm1Wsh/Asic3^tm1Wsh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

behavior/neurological

hyperalgesia ( J:73505 )

• at site of injury (carrageenan-induced inflammation), mice showed increased sensitivity to mechanical stimuli, but not to noxious thermal stimulus

• responses to somatosensory stimuli under normal conditions were similar to wild-type littermates

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:89141 )

• at 2 months, homozygotes display no vestibular phenotype (such as head tossing, circling or hyperactivity) and no significant differences in the latency, form or sensitivity of ABR thresholds relative to wild-type mice

• at 2 and 4 months, homozygotes show an ABR threshold of 47 dB and 68 dB, respectively, whereas wild-type thresholds are 42 dB at both ages

• at 6 months or later, homozygotes continue to display an elevation of 20 dB or higher in ABR thresholds relative to wild-type

• however, no significant differences in ABR thresholds are noted between wild-type and mutant mice at 10 months