All Phenotypes Brca1<tm2Mak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca1^tm2Mak
targeted mutation 2, Tak W Mak
MGI:2429692

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Brca1^tm2Mak/Brca1^tm2Mak Tg(Lck-cre)548Jxm/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834729
cn2	Brca1^tm2Mak/Brca1^tm2Mak Tg(Lck-cre)548Jxm/? Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834730
cn3	Brca1^tm2Mak/Brca1^tm2Mak Tg(BCL2)36Wehi/? Tg(Lck-cre)548Jxm/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834731
cn4	Brca1^tm2Mak/Brca1^tm2Mak Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Tg(Lck-cre)548Jxm/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834732
cn5	Brca1^tm2Mak/Brca1^tm2Mak Tg(Lck-cre)548Jxm/? Tg(TcrLCMV)327Sdz/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834733
cn6	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Lck-cre)548Jxm/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834734
cn7	Brca1^tm2Mak/Brca1^tm2Mak Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834735
cn8	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834736
cn9	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53⁺ Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834737
cn10	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53^tm1Brd Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834738

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Tg(Lck-cre)548Jxm/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:63282 )

• reduced proliferation when stimulated with monoclonal antibody to CD3e

abnormal T cell number ( J:63282 )

increased double-negative T cell number ( J:63282 )

• increased proportion of double negative thymocytes

• absolute number of double negative thymocytes is normal

decreased double-positive T cell number ( J:63282 )

• less than 10% of number in controls

decreased single-positive T cell number ( J:63282 )

• less than 10% of number in controls

abnormal immune system organ morphology ( J:63282 )

decreased thymocyte number ( J:63282 )

• 90% reduction in thymocyte number

cellular

abnormal cell cycle checkpoint function ( J:63282 )

• fewer T cells entering S phase

abnormal cell death ( J:63282 )

• reduced viability of thymocytes in culture

• reduced survival of T cells when stimulated with monoclonal antibody to CD3e

increased cellular sensitivity to gamma-irradiation ( J:63282 )

• increased thymocyte sensitivity of gamma-irradiation

decreased T cell proliferation ( J:63282 )

• reduced proliferation when stimulated with monoclonal antibody to CD3e

neoplasm

increased tumor incidence ( J:90512 )

• only about 12% with tumors

• most tumors are peripheral rather than thymic

hematopoietic system

decreased T cell proliferation ( J:63282 )

• reduced proliferation when stimulated with monoclonal antibody to CD3e

abnormal T cell number ( J:63282 )

decreased thymocyte number ( J:63282 )

• 90% reduction in thymocyte number

increased double-negative T cell number ( J:63282 )

• increased proportion of double negative thymocytes

• absolute number of double negative thymocytes is normal

decreased double-positive T cell number ( J:63282 )

• less than 10% of number in controls

decreased single-positive T cell number ( J:63282 )

• less than 10% of number in controls

endocrine/exocrine glands

decreased thymocyte number ( J:63282 )

• 90% reduction in thymocyte number

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Tg(Lck-cre)548Jxm/? Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

mortality/aging

premature death ( J:90512 )

• most mice with thymic lymphomas are moribund or die by 3 months of age

cellular

chromosomal instability ( J:63282 )

• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

spontaneous chromosome breakage ( J:63282 )

immune system

immune system phenotype ( J:63282 )

N	• thymus cellularity restored • T cell numbers in lymph nodes are improved

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

neoplasm

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

hematopoietic system

increased T cell derived lymphoma incidence ( J:90512 )

• increased incidence

• reduced latency

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Tg(BCL2)36Wehi/? Tg(Lck-cre)548Jxm/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(BCL2)36Wehi mutation (2 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:63282 )

• increased frequency of aberrations such as polyploidy, quadriradial chromosomes, and telomeric translocations

spontaneous chromosome breakage ( J:63282 )

immune system

immune system phenotype ( J:63282 )

N	• thymus cellularity restored

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Tg(Lck-cre)548Jxm/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Cdkn1a^tm1Tyj mutation (3 available); any Cdkn1a mutation (63 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:63282 )

N	• T cell numbers in lymph nodes are more nearly normal

decreased thymocyte number ( J:63282 )

hematopoietic system

decreased thymocyte number ( J:63282 )

endocrine/exocrine glands

decreased thymocyte number ( J:63282 )

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Tg(Lck-cre)548Jxm/? Tg(TcrLCMV)327Sdz/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:63282 )

abnormal T cell number ( J:63282 )

decreased thymocyte number ( J:63282 )

increased double-negative T cell number ( J:63282 )

decreased double-positive T cell number ( J:63282 )

hematopoietic system

decreased T cell proliferation ( J:63282 )

abnormal T cell number ( J:63282 )

decreased thymocyte number ( J:63282 )

increased double-negative T cell number ( J:63282 )

decreased double-positive T cell number ( J:63282 )

endocrine/exocrine glands

decreased thymocyte number ( J:63282 )

cellular

decreased T cell proliferation ( J:63282 )

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Lck-cre)548Jxm/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (54 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

immune system

immune system phenotype ( J:90512 )

N	• complete thymocyte restoration • T cell numbers in the periphery are restored

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

cellular

cellular phenotype ( J:90512 )

N	• resistant to gamma irradiation • restoration of normal cell cycle arrest of T cells when stimulated with antibody to CD3e or CD3 and Il2

chromosomal instability ( J:90512 )

• increased frequency

neoplasm

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

hematopoietic system

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:90512 )

• only a mild predisposition to mammary cancer (12%)

integument

increased mammary gland tumor incidence ( J:90512 )

• only a mild predisposition to mammary cancer (12%)

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:90512 )

• only a mild predisposition to mammary cancer (12%)

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

integument

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53⁺ Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (114 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:90512 )

• about 80% develop acinar adenocarcenomas

integument

increased mammary adenocarcinoma incidence ( J:90512 )

• about 80% develop acinar adenocarcenomas

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:90512 )

• about 80% develop acinar adenocarcenomas

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53^tm1Brd Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:90512 )

• usually succumb early to other tumors before developing mammary tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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