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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SERPINA1-BCL2)1Pva
transgene insertion 1, Pierre Vassalli
MGI:2429696
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Relatm1Bal/Relatm1Bal
Tg(SERPINA1-BCL2)1Pva/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:3799177


Genotype
MGI:3799177
cx1
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Tg(SERPINA1-BCL2)1Pva/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Tg(SERPINA1-BCL2)1Pva mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte apoptosis ( J:126292 )
• over-expression of Bcl-2 transgene fails to prevent hepatocyte apoptosis induced by endogenous TNF-alpha

cellular
increased hepatocyte apoptosis ( J:126292 )
• over-expression of Bcl-2 transgene fails to prevent hepatocyte apoptosis induced by endogenous TNF-alpha




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory