Phenotypes associated with this allele

• Allele Symbol: Itgal^tm1Wpfl
• Allele Name: targeted mutation 1, Wai-Ping Fung-Leung
• Allele ID: MGI:2429755
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgal^tm1Wpfl/Itgal^tm1Wpfl	involves: 129	MGI:3834484

Genotype
MGI:3834484

hm1

• Allelic Composition: Itgal^tm1Wpfl/Itgal^tm1Wpfl
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:37160 )

N • normal sized lymph organs although peripheral lymph nodes are usually on the small end of the normal size range

N • normal cell counts and normal distribution of leukocyte subsets

N • natural killer cell function normal

N • delayed type hypersensitivity is normal

N • neutrophile migration in response to intradermal lipopolysaccharide injection is normal

abnormal leukocyte physiology ( J:37160 )

• fail to aggregate after treatment with PMA

abnormal lymphocyte physiology ( J:37160 )

• proliferative response of splenocytes in a mixed leukocyte reaction is significantly reduced

• proliferative response of spleen cells to the T cell lectin Con A is drastically reduced

abnormal cytotoxic T cell physiology ( J:37160 )

• less efficient in their cytotoxicity to allogeneic target cells

• activity partially restored by Il2 supplementation

lymph node hyperplasia ( J:37160 )

• popliteal lymph node hyperplasia iis decreased in host vs graft reactions

neoplasm

increased metastatic potential ( J:37160 )

• higher number of tumors develop in the B16 melanoma metastasis model

hematopoietic system

abnormal leukocyte physiology ( J:37160 )

• fail to aggregate after treatment with PMA

abnormal lymphocyte physiology ( J:37160 )

• proliferative response of splenocytes in a mixed leukocyte reaction is significantly reduced

• proliferative response of spleen cells to the T cell lectin Con A is drastically reduced

abnormal cytotoxic T cell physiology ( J:37160 )

• less efficient in their cytotoxicity to allogeneic target cells

• activity partially restored by Il2 supplementation