Phenotypes associated with this allele

• Allele Symbol: Tg(YAC72)2511Hay
• Allele Name: transgene insertion 2511, Michael Hayden
• Allele ID: MGI:2429756
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Htt^tm1Hay/Htt^tm1Hay Tg(YAC72)2511Hay/0	involves: FVB/N	MGI:5298845
cx2	Htt^tm1Hay/Htt^+ Tg(YAC72)2511Hay/0	involves: FVB/N	MGI:5298846
tg3	Tg(YAC72)2511Hay/Tg(YAC72)2511Hay	FVB/N-Tg(YAC72)2511Hay	MGI:5432191
tg4	Tg(YAC72)2511Hay/0	involves: FVB/N	MGI:5298847
tg5	Tg(YAC72)2511Hay/?	involves: FVB/N	MGI:3722277

Genotype
MGI:5298845

cx1

• Allelic Composition: Htt^tm1Hay/Htt^tm1Hay; Tg(YAC72)2511Hay/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:67366 )

N • embryonic lethality observed in Htt^tm1Hay homozygotes is rescued

reproductive system

reproductive system phenotype ( J:67366 )

♀N • female mice are fertile

oligozoospermia ( J:67366 )

♂ • at 4 months

abnormal spermatid morphology ( J:67366 )

♂ • degenerating

multinucleated giant male germ cells ( J:67366 )

♂ • testes contain giant multinucleated cells and protein aggregates

abnormal male germ cell apoptosis ( J:67366 )

♂

testicular atrophy ( J:67366 )

♂

male infertility ( J:67366 )

♂

cellular

oligozoospermia ( J:67366 )

♂ • at 4 months

abnormal spermatid morphology ( J:67366 )

♂ • degenerating

multinucleated giant male germ cells ( J:67366 )

♂ • testes contain giant multinucleated cells and protein aggregates

abnormal male germ cell apoptosis ( J:67366 )

♂

endocrine/exocrine glands

testicular atrophy ( J:67366 )

♂

Genotype
MGI:5298846

cx2

• Allelic Composition: Htt^tm1Hay/Htt⁺; Tg(YAC72)2511Hay/0
• Genetic Background: involves: FVB/N

reproductive system

testicular atrophy ( J:67366 )

♂ • in some mice

endocrine/exocrine glands

testicular atrophy ( J:67366 )

♂ • in some mice

Genotype
MGI:5432191

tg3

• Allelic Composition: Tg(YAC72)2511Hay/Tg(YAC72)2511Hay
• Genetic Background: FVB/N-Tg(YAC72)2511Hay

nervous system

increased neuron apoptosis ( J:105728 )

• general increase in stress-induced apoptosis in primary cultures of striatal neurons

• in cultured striatal medium spiny neurons in response to mitochondria stress

increased susceptibility to neuronal excitotoxicity ( J:105728 )

• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176

• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:105728 )

• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176

• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

cellular

increased neuron apoptosis ( J:105728 )

• general increase in stress-induced apoptosis in primary cultures of striatal neurons

• in cultured striatal medium spiny neurons in response to mitochondria stress

increased susceptibility to neuronal excitotoxicity ( J:105728 )

• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176

• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:105728

Genotype
MGI:5298847

tg4

• Allelic Composition: Tg(YAC72)2511Hay/0
• Genetic Background: involves: FVB/N

reproductive system

reproductive system phenotype ( J:67366 )

N • mice exhibit normal testes and are fertile

nervous system

increased susceptibility to neuronal excitotoxicity ( J:144917 )

• NMDA or glutamate receptor-mediated

cellular

increased susceptibility to neuronal excitotoxicity ( J:144917 )

• NMDA or glutamate receptor-mediated

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:144917 )

• NMDA or glutamate receptor-mediated

Genotype
MGI:3722277

tg5

• Allelic Composition: Tg(YAC72)2511Hay/?
• Genetic Background: involves: FVB/N

nervous system

abnormal striatum morphology ( J:55405 )

• nuclear translocation of the N-terminal portion of HD is observed in striatal neurons of 12 month old mice with an immunoreactive antibody (EM48)

neuron degeneration ( J:55405 )

• selective degeneration is observed in the striatum at 12 months of age

• neurons are shrunken and hyperchromatic

abnormal excitatory postsynaptic potential ( J:55405 )

• hippocampal slices from 6 month old mice display a hyperexcitability exhibited as a broad EPSP at the distal dendrites

enhanced NMDA-mediated synaptic currents ( J:55405 )

• fast synaptic response in these mice has a prominent NMDA component

abnormal long-term potentiation ( J:55405 )

• following tetanization most slices from 6 month old mice exhibit a greater short-term potentiation when compared to controls

reduced long-term potentiation ( J:55405 )

• by 10 months of age, LTP is not induced in CA1 neurons; high frequency stimulation induces depression instead of potentiation

behavior/neurological

hyperactivity ( J:55405 )

• progressive hyperactivity is observed in the dark phase of open field testing beginning at 7 months of age

unidirectional circling ( J:55405 )

• circling was observed in one mouse at 8.5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:55405