Phenotypes associated with this allele

• Allele Symbol: Disp1^tm1Ptch
• Allele Name: targeted mutation 1, Pao-Tien Chuang
• Allele ID: MGI:2429759
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Disp1^tm1Ptch/Disp1^tm1Ptch	involves: 129P2/OlaHsd	MGI:3629735

Genotype
MGI:3629735

hm1

• Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79831 )

• homozygotes fail to survive beyond E9.5, probably due to abnormal heart development

embryo

incomplete embryo turning ( J:79831 )

• at E9.5, homozygotes have initiated but fail to complete embryo turning

abnormal left-right axis symmetry of the somites ( J:79831 )

• at E9.5, homozygotes exhibit multiple defects in L-R axis determination

abnormal neural tube morphology ( J:79831 )

absent floor plate ( J:79831 )

cardiovascular system

abnormal heart development ( J:79831 )

• at E9.5, homozygotes still display a linear heart tube instead of a multi-chambered heart

failure of heart looping ( J:79831 )

• at E8.0, homozygotes fail to undergo normal rightward cardiac looping

distended pericardium ( J:79831 )

• at E9.5, the mutant heart remains as a linear tube and is surrounded by a distended pericardial sac

nervous system

abnormal neural tube morphology ( J:79831 )

absent floor plate ( J:79831 )

holoprosencephaly ( J:79831 )

abnormal forebrain morphology ( J:79831 )

• at E8.5, homozygotes show abnormal forebrain morphology, indicating loss of ventral midline fate

vision/eye

cyclopia ( J:79831 )

muscle

abnormal dermomyotome development ( J:79831 )

• at E9.5, homozygotes have initiated but fail to complete dermomyotomal development

skeleton

abnormal sclerotome morphology ( J:79831 )