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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efna5tm1Wrst
targeted mutation 1, Wolfgang Wurst
MGI:2429768
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Efna5tm1Wrst/Efna5tm1Wrst Not Specified MGI:4358399
cx2
 		Efna5tm1Wrst/Efna5tm1Wrst
Vmn1r51tm2.1Dlc/Vmn1r51tm2.1Dlc 		involves: 129 * C57BL/6 MGI:4358394


Genotype
MGI:4358399
hm1
Allelic
Composition		 Efna5tm1Wrst/Efna5tm1Wrst
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna5tm1Wrst mutation (0 available); any Efna5 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:79997 )
• limbic thalamic neurons from the laterodorsal nucleus form additional projections to somatosensory cortical territories compared to in wild-type mice

cellular
abnormal neuronal migration ( J:79997 )
• limbic thalamic neurons from the laterodorsal nucleus form additional projections to somatosensory cortical territories compared to in wild-type mice




Genotype
MGI:4358394
cx2
Allelic
Composition		 Efna5tm1Wrst/Efna5tm1Wrst
Vmn1r51tm2.1Dlc/Vmn1r51tm2.1Dlc
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efna5tm1Wrst mutation (0 available); any Efna5 mutation (28 available)
Vmn1r51tm2.1Dlc mutation (1 available); any Vmn1r51 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal accessory olfactory bulb morphology ( J:67679 )
• axon project to both the anterior and posterior halves of the accessory olfactory bulb unlike in wild-type mice
• unlike in wild-type mice, axons predominantly form glomeruli in the medial third of the accessory olfactory bulb closest to the vomeronasal nerve
• glomeruli are shifted towards the posterior pole compared to in wild-type mice
• however, the number and structure of olfactory bulb glomeruli are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory