Phenotypes associated with this allele

• Allele Symbol: Snca^tm1Wtd
• Allele Name: targeted mutation 1, William T Dauer
• Allele ID: MGI:2429773
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snca^tm1Wtd/Snca^tm1Wtd	involves: 129	MGI:3834399
cx2	Atp13a2^tm1.2Wtd/Atp13a2^tm1.2Wtd Snca^tm1Wtd/Snca^tm1Wtd	involves: 129 * C57BL/6	MGI:5642336

Genotype
MGI:3834399

hm1

• Allelic Composition: Snca^tm1Wtd/Snca^tm1Wtd
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:79993 )

• resistant to the neurotoxic effects of MPTP (1methyl-4phenyl-1,2,3,6-tetrahydropyridine)

increased physiological sensitivity to xenobiotic ( J:79993 )

• increased sensitivity to rotenone

cellular

cellular phenotype ( J:101289 )

N • cell survival or apoptosis in the absence of nerve growth factor is comparable to controls

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:79993 )

• resistant to the neurotoxic effects of MPTP (1methyl-4phenyl-1,2,3,6-tetrahydropyridine)

abnormal respiratory electron transport chain ( J:79993 )

• complex I inhibition by MPTP is prevented

nervous system

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:79993 )

• resistant to the neurotoxic effects of MPTP (1methyl-4phenyl-1,2,3,6-tetrahydropyridine)

abnormal synaptic transmission ( J:94390 )

• glutamate stimulation fails to cause an increase in active bouton number

reduced long-term potentiation ( J:94390 , J:126092 )

• no potentiation following high frequency stimulation (J:94390)

• no potentiation following DEA/NO application (J:126092)

• no potentiation following 8-Br-cGMP administration (J:126092)

abnormal miniature excitatory postsynaptic currents ( J:94390 , J:126092 )

• frequency increase following glutamate treatment is reduced (J:94390)

• DEA/NO application fails to increase mEPSC frequency in cultured hippocampal neurons (J:126092)

• 8-Br-cGMP administration fails to increase mEPSC frequency in cultured hippocampal neurons (J:126092)

Genotype
MGI:5642336

cx2

• Allelic Composition: Atp13a2^tm1.2Wtd/Atp13a2^tm1.2Wtd; Snca^tm1Wtd/Snca^tm1Wtd
• Genetic Background: involves: 129 * C57BL/6

cellular

abnormal lysosome morphology ( J:221680 )

• mice show a similar level of lysosomal accumulation as seen in single Atp13a2 homozygotes

nervous system

gliosis ( J:221680 )

• mice show increase in the extent of gliosis compared to single Atp13a2 homozygotes