Phenotypes associated with this allele

• Allele Symbol: Nmf31
• Allele Name: neuroscience mutagenesis facility, 31
• Allele ID: MGI:2429921
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nmf31/Nmf31	BALB/cByJ-Nmf31/J	MGI:3054786
ht2	Nmf31/Nmf31^+	BALB/cByJ-Nmf31/J	MGI:2429922

Genotype
MGI:3054786

hm1

• Allelic Composition: Nmf31/Nmf31
• Genetic Background: BALB/cByJ-Nmf31/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:87349 )

• homozygous mutants die within a few days of the onset of the overt phenotype

behavior/neurological

myoclonus ( J:87349 )

• at 3-6 days of age, homozygotes exhibit intermittent, intense limb spasms, lasting several seconds, in which front paws are drawn close to the chest and hind limbs are extended straight backwards

muscle

myoclonus ( J:87349 )

• at 3-6 days of age, homozygotes exhibit intermittent, intense limb spasms, lasting several seconds, in which front paws are drawn close to the chest and hind limbs are extended straight backwards

respiratory system

respiratory distress ( J:87349 )

• homozygous mutants appear to have difficulty breathing

nervous system

myoclonus ( J:87349 )

• at 3-6 days of age, homozygotes exhibit intermittent, intense limb spasms, lasting several seconds, in which front paws are drawn close to the chest and hind limbs are extended straight backwards

Genotype
MGI:2429922

ht2

• Allelic Composition: Nmf31/Nmf31⁺
• Genetic Background: BALB/cByJ-Nmf31/J

behavior/neurological

minimal clonic seizures ( J:78134 )

• deviants have a high threshold to electroconvulsive minimal clonic seizures (show relative resistance compared with the parental strain)

• mutants do not appear to be resistant to pentylenetetrazole (PTZ)-induced seizures

• using other seizure endpoints (clonus, tonic hind limb extension) similar results were observed compared to controls

nervous system

nervous system phenotype ( J:78134 )

N • standard pathological analysis revealed no apparent defects in the brain; in particular, the hippocampus appeared normal

minimal clonic seizures ( J:78134 )

• deviants have a high threshold to electroconvulsive minimal clonic seizures (show relative resistance compared with the parental strain)

• mutants do not appear to be resistant to pentylenetetrazole (PTZ)-induced seizures

• using other seizure endpoints (clonus, tonic hind limb extension) similar results were observed compared to controls