All Phenotypes Gata1<tm5(GATA3)Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^{tm5(GATA3)Sho}
targeted mutation 5, Stuart Orkin
MGI:2429992

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gata1^{tm5(GATA3)Sho}/Gata1⁺	involves: 129S4/SvJae * C57BL/6	MGI:3820409
ot2	Gata1^{tm5(GATA3)Sho}/Y	involves: 129S4/SvJae * C57BL/6	MGI:3820408

Allelic Composition	Gata1^{tm5(GATA3)Sho}/Gata1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^{tm5(GATA3)Sho} mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:47295 )

• only two thirds of expected female mice survive into adulthood

lethality throughout fetal growth and development, incomplete penetrance ( J:47295 )

• one third of female mice die after E15.5 of severe anemia

embryonic lethality during organogenesis, incomplete penetrance ( J:47295 )

• some female mice die between E11.5 and E14.5

hematopoietic system

abnormal definitive hematopoiesis ( J:47295 )

• at E15.5, most female mice exhibit an increase in circulating immature hematopoitic cells compared to in wild-type mice

anemia ( J:47295 )

• one third of female mice die after E15.5 of severe anemia

decreased erythrocyte cell number ( J:47295 )

• at E15.5, most female mice exhibit reduced total erythroid cells compared to in wild-type mice

embryo

pale yolk sac ( J:47295 )

• at E14.6 and E16.5

integument

pallor ( J:47295 )

• beyond E15.5, most female mice look pale

Allelic Composition	Gata1^{tm5(GATA3)Sho}/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^{tm5(GATA3)Sho} mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:47295 )

• mice die by E13.5

hematopoietic system

abnormal erythropoiesis ( J:47295 )

• at E10.5, erythropoeisis is arrested at the proerythroblast stage and total cell numbers are 70% of wild-type

• however, erythroid development can be partially rescued in cultured ES cells

anemia ( J:47295 )

embryo

decreased embryo size ( J:47295 )

• at E11.5 to E12.5

pale yolk sac ( J:47295 )

• at E10.5, yolk sacs are pink instead of red as in wild-type mice

cardiovascular system

enlarged pericardium ( J:47295 )

• at E11.5 to E12.5

growth/size/body

decreased embryo size ( J:47295 )

• at E11.5 to E12.5

integument

pallor ( J:47295 )

• at E11.5 to E12.5, mice are pale

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