All Phenotypes Gata1<tm5(GATA3)Sho> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^{tm5(GATA3)Sho}
targeted mutation 5, Stuart Orkin
MGI:2429992

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gata1^{tm5(GATA3)Sho}/Gata1⁺	involves: 129S4/SvJae * C57BL/6	MGI:3820409
ot2	Gata1^{tm5(GATA3)Sho}/Y	involves: 129S4/SvJae * C57BL/6	MGI:3820408

Allelic Composition	Gata1^{tm5(GATA3)Sho}/Gata1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^{tm5(GATA3)Sho} mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:47295 )

• only two thirds of expected female mice survive into adulthood

lethality throughout fetal growth and development, incomplete penetrance ( J:47295 )

• one third of female mice die after E15.5 of severe anemia

embryonic lethality during organogenesis, incomplete penetrance ( J:47295 )

• some female mice die between E11.5 and E14.5

hematopoietic system

abnormal definitive hematopoiesis ( J:47295 )

• at E15.5, most female mice exhibit an increase in circulating immature hematopoitic cells compared to in wild-type mice

anemia ( J:47295 )

• one third of female mice die after E15.5 of severe anemia

decreased erythrocyte cell number ( J:47295 )

• at E15.5, most female mice exhibit reduced total erythroid cells compared to in wild-type mice

embryo

pale yolk sac ( J:47295 )

• at E14.6 and E16.5

integument

pallor ( J:47295 )

• beyond E15.5, most female mice look pale

Allelic Composition	Gata1^{tm5(GATA3)Sho}/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^{tm5(GATA3)Sho} mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:47295 )

• mice die by E13.5

hematopoietic system

abnormal erythropoiesis ( J:47295 )

• at E10.5, erythropoeisis is arrested at the proerythroblast stage and total cell numbers are 70% of wild-type

• however, erythroid development can be partially rescued in cultured ES cells

anemia ( J:47295 )

embryo

decreased embryo size ( J:47295 )

• at E11.5 to E12.5

pale yolk sac ( J:47295 )

• at E10.5, yolk sacs are pink instead of red as in wild-type mice

cardiovascular system

enlarged pericardium ( J:47295 )

• at E11.5 to E12.5

growth/size/body

decreased embryo size ( J:47295 )

• at E11.5 to E12.5

integument

pallor ( J:47295 )

• at E11.5 to E12.5, mice are pale

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24