All Phenotypes Slc6a4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc6a4⁺
wild type
MGI:2430009

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slc6a4^tm1Kpl/Slc6a4⁺	B6.129-Slc6a4^tm1Kpl	MGI:5467728
ht2	Slc6a4^tm1Kpl/Slc6a4⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3056092
ht3	Slc6a4^tm1Kpl/Slc6a4⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3056080
ht4	Slc6a4^tm1(cre)Xz/Slc6a4⁺	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3691580
cn5	Slc18a2^tm1.1Bgir/Slc18a2^tm1.1Bgir Slc6a4^tm1(cre)Xz/Slc6a4⁺	involves: 129S1/Sv * C57BL/6J	MGI:5497000
cn6	Htr2a^tm1Grch/Htr2a^tm2Grch Slc6a4^tm1(cre)Grch/Slc6a4⁺	involves: 129S6/SvEvTac	MGI:3663444
cx7	Pten^tm1Rps/Pten⁺ Slc6a4^tm1Kpl/Slc6a4⁺	B6.129-Slc6a4^tm1Kpl Pten^tm1Rps	MGI:5467729
cx8	Slc6a3^tm1Mca/Slc6a3^tm1Mca Slc6a4^tm1Kpl/Slc6a4⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3056097
cx9	Htr1a^tm3.1Rhn/Htr1a^tm3.1Rhn Slc6a4^tm1(tTA)Cogr/Slc6a4⁺	involves: 129S1/Sv * BALB/cJ * C57BL/6 * CBA	MGI:3802744

Allelic Composition	Slc6a4^tm1Kpl/Slc6a4⁺
Genetic Background	B6.129-Slc6a4^tm1Kpl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4^tm1Kpl mutation (3 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal social investigation ( J:144937 )

• 8 week old females show a trend towards decreased preference for interacting with a stimulus mouse in a social approach assay, however this does not reach significance

• while 8 week old males do not show a change in preference for social interaction for the first trial, upon reexposure to the same social target in trial 2, males do not show attenuation of preference for social investigation between the first and second trials as seen in wild-type mice, indicating impaired social recognition in male

nervous system

increased brain weight ( J:144937 )

growth/size/body

megacephaly ( J:144937 )

Allelic Composition	Slc6a4^tm1Kpl/Slc6a4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4^tm1Kpl mutation (3 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal barrel cortex morphology ( J:71182 )

• the barrel septa in layer IV of the somatosensory cortex are enlarged

behavior/neurological

enhanced conditioned place preference behavior ( J:48275 )

• cocaine-conditioned place preference is significantly enhanced compared to wild-type mice

Allelic Composition	Slc6a4^tm1Kpl/Slc6a4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4^tm1Kpl mutation (3 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:76020 )

• cumulative (+)3,4-methylenedioxymethamphetamine (MDMA) induced hyperactivity is reduced by about 50% compared to wild-type

Allelic Composition	Slc6a4^tm1(cre)Xz/Slc6a4⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4^tm1(cre)Xz mutation (2 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:115426 )

• mice are viable and fertile

Allelic Composition	Slc18a2^tm1.1Bgir/Slc18a2^tm1.1Bgir Slc6a4^tm1(cre)Xz/Slc6a4⁺
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc18a2^tm1.1Bgir mutation (0 available); any Slc18a2 mutation (29 available)
Slc6a4^tm1(cre)Xz mutation (2 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:197966 )

• some mice die between P1 and P30

behavior/neurological

abnormal emotion/affect behavior ( J:197966 )

• in a tail suspension test, mice exhibit an increase in active defense behavior indicated by increased time spent struggling to escape and decreased immobilization compared with wild-type mice

• in response to aversive ultrasonic stimulus, mice exhibit a large increase in behavioral reactivity with less freezing compared with wild-type mice

• however, mice treated with pargyline exhibit normal flight responses in response to ultrasonic stimulus

decreased anxiety-related response ( J:197966 )

• in a novelty-suppressed feeding test, mice exhibit faster initiation of feeding compared with wild-type mice

decreased locomotor activity ( J:197966 )

• in an elevated plus maze

homeostasis/metabolism

abnormal catecholamine level ( J:197966 )

• decreased in the hippocampus but not the cortex or striatum

decreased serotonin level ( J:197966 )

• in the brain (cortex, striatum and brain stem) and blood

• mice treated with pargyline exhibit lower 5-HT levels compared with wild-type mice

• however, mice exhibit normal 5-HIAA brain levels and serotonin gut levels

nervous system

nervous system phenotype ( J:197966 )

N	• 5-HT raphe neurons develop normally

Allelic Composition	Htr2a^tm1Grch/Htr2a^tm2Grch Slc6a4^tm1(cre)Grch/Slc6a4⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2a^tm1Grch mutation (0 available); any Htr2a mutation (42 available)
Htr2a^tm2Grch mutation (0 available); any Htr2a mutation (42 available)
Slc6a4^tm1(cre)Grch mutation (0 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:110958 )

• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test

• selective restoration of 5HT2AR signaling to the thalamus did not normalized conflict anxiety behaviors

Allelic Composition	Pten^tm1Rps/Pten⁺ Slc6a4^tm1Kpl/Slc6a4⁺
Genetic Background	B6.129-Slc6a4^tm1Kpl Pten^tm1Rps

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Rps mutation (1 available); any Pten mutation (82 available)
Slc6a4^tm1Kpl mutation (3 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal social investigation ( J:144937 )

• 8 week old females show a significant decrease in preference for interacting with a stimulus mouse in a social approach assay, with mice spending significantly less time interacting with the stimulus mouse than in wild-type mice or either single heterozygote, indicating impaired social approach behavior in females

nervous system

increased brain weight ( J:144937 )

reduced sensorimotor gating ( J:144937 )

• deficits in prepulse inhibition of the acoustic startle response indicate impaired sensorimotor gating

decreased prepulse inhibition ( J:144937 )

• mice show deficits in prepulse inhibition of the acoustic startle response to a similar level as single Pten heterozygotes

• however, mice respond to the olfactory-habituation-dishabituation test normally, indicating normal olfactory function

growth/size/body

megacephaly ( J:144937 )

• macrocephaly that is more severe than in either single heterozygote

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:144937

Allelic Composition	Slc6a3^tm1Mca/Slc6a3^tm1Mca Slc6a4^tm1Kpl/Slc6a4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a3^tm1Mca mutation (1 available); any Slc6a3 mutation (66 available)
Slc6a4^tm1Kpl mutation (3 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired conditioned place preference behavior ( J:93114 )

• mutants do not display any cocaine place preference

Allelic Composition	Htr1a^tm3.1Rhn/Htr1a^tm3.1Rhn Slc6a4^tm1(tTA)Cogr/Slc6a4⁺
Genetic Background	involves: 129S1/Sv * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1a^tm3.1Rhn mutation (1 available); any Htr1a mutation (26 available)
Slc6a4^tm1(tTA)Cogr mutation (1 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:137439 )

• 30% of mice survive beyond P120

• fewer mice die when over-expression begins at P60 instead of P40

premature death ( J:137439 )

• most mice die before 3 months of age frequently between P25 and P80

• in 37% of mice, crises of severe bradycardia and hypothermia progress to death

• however, 30% of mice survive beyond P120 and treatment with doxycycline prevents premature death

nervous system

abnormal autonomic nervous system physiology ( J:137439 )

• mice exhibit sporadic autonomic crisis, involving bradycardia preceded 5 to 10 minutes by hypothermia, that persists for several hours and is followed by several days of recovery or, in the case of 37% of mice, progresses to death

abnormal neuron physiology ( J:137439 )

• following treatment of brain slices with tryptophan, cells exhibit reduced firing compared to wild-type cells

• however, normal cell firing can be re-established by treatment with doxycycline

cardiovascular system

decreased heart rate ( J:137439 )

• mice exhibit sporadic autonomic crises involving a decrease in heart rate and temperature than persists for several hours followed by several days of recovery

• bradycardia precedes hypothermia by 5 to 10 minutes

homeostasis/metabolism

decreased body temperature ( J:137439 )

• mice exhibit sporadic autonomic crises involving a decrease in heart rate and temperature than persists for several hours followed by several days of recovery

• bradycardia precedes hypothermia by 5 to 10 minutes

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