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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctsb+
wild type
MGI:2430331
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ctsbtm1Jde/Ctsb+ NOD.129P2-Ctsbtm1Jde MGI:4421159
cx2
 		Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Ctsbtm1Jde/Ctsb+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5467737


Genotype
MGI:4421159
ht1
Allelic
Composition		 Ctsbtm1Jde/Ctsb+
Genetic
Background		 NOD.129P2-Ctsbtm1Jde
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsbtm1Jde mutation (3 available); any Ctsb mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
insulitis ( J:153355 )
• insulitis scores for diabetic animals are similar to diabetic NOD controls
decreased susceptibility to autoimmune diabetes ( J:153355 )
• 50% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age as compared to 69% of NOD controls

homeostasis/metabolism

endocrine/exocrine glands
insulitis ( J:153355 )
• insulitis scores for diabetic animals are similar to diabetic NOD controls




Genotype
MGI:5467737
cx2
Allelic
Composition		 Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Ctsbtm1Jde/Ctsb+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm2.1Kewa mutation (0 available); any Cacna1a mutation (117 available)
Ctsbtm1Jde mutation (3 available); any Ctsb mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal motor coordination/balance ( J:190729 )
• impaired performance on the rotarod at 9 weeks of age
• performance is worse than in mice homozygous for Cacna1atm2.1Kewa alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory