Analysis Tools
homeostasis/metabolism
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• 7 of 28 mice develop chylous ascites unlike wild-type mice
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Allele Symbol Allele Name Allele ID |
Flt4+ wild type MGI:2430679 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 7 of 28 mice develop chylous ascites unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mesenteric lymphatic vessels appear diffuse suggesting that they are leaky and dysfunctional
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• only some remnants of lymphatic vessels are present in the skin at E17.5
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• appear swollen at E14.5
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• transient accumulation of chylous ascites in the abdomen after birth
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• mesenteric lymphatic vessels appear diffuse suggesting that they are leaky and dysfunctional
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Defective lymphatic vessels in the Flt4Chy/Flt4+ mice
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• the 10% of pups with severe chylous ascites die before weaning
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• at weaning the hind feet are swollen and edematous
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• milky fluid accumulates in the abdomen after their first feeding
(J:13981)
• chylous ascites are seen in all embryos with about 10% developing severe fluid accumulation and dying, the rest spontaneously resorb the fluid and appear healthy after weaning
(J:72387)
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• dye injected into the hind foot pad fails to be transported into deeper lymphatic vessels
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• lymphatic vessels in the intestinal submucosa are enlarged
• lymphatic vessels are mostly absent from the skin with only a few enlarged cutaneous vessels present; however, viral overexpression of Flt4 ligand can induce lymphatic vessel development
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• mice lack lymphatic vessel growth towards the dorsal central line with few enlarged lymphatic vessels around the forelimb skin
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• mice with severe fluid accumulation also have histopathological changes in the liver
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• mice with severe fluid accumulation also have fibrinous adhesions in the intestinal tract
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• the subcutaneous adipose tissue is thickened
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| N |
• both sexes are fertile
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• dye injected into the hind foot pad fails to be transported into deeper lymphatic vessels
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary lymphedema | DOID:0050580 |
OMIM:PS153100 |
J:72387 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1 of 13 mice develop chylous ascites unlike wild-type mice
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• a few mice exhibit lymphatic vessel hypoplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no mice exhibit chylous ascites
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• intestinal
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• all mice develop chylous ascites unlike wild-type mice
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• mice develop lymphatic vessel hypoplasia unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abnormal smooth muscle cell coating
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• enlarged lymphatic vessels are even more dilated than in Tmem204tm1.1Ali single knock-outs
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• abnormal smooth muscle cell coating
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• enlarged lymph vessel in the dorsal trunk skin at P0
• poor branching in the dorsal trunk skin at P0 (<5%, compare with wild-type)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Abnormal lymphatic development in Nrp2tm1Ddg/Nrp2+ Flt4tm1Ali/Flt4+ mice
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• recovered at reduced Mendelian ratios at birth
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• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward
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• poorly branched lymphatic vessels and rare lymphatic tips in the skin at P0
• 50% reduction in the number of branch points in the skin at P0
• reduced lymph vessel branching in hearts, ears and diaphragm at 2 months
• tail dermal lymphatics are missing until at least P6
• reduced lymphatic vascular coverage in the skin at E13.5
• reduced sprouting and enlarged lymphatic vessels in the skin at E13.5, in the tail at P1, in the heart at P5 and in the small intestine at P4
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• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduction or absence of the formation of the superficial capillary plexus/network due to the disruption of endothelial cell sprouting, with the cells failing to take the characteristic elongated morphology and instead having the mutant lymphatic vascular plexus depicting few rounded bumps
• failed to remodel the primary lymphatic capillary plexus into a hierarchical vessel network
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• hyperplastic collecting lymphatic vessels in the ischiatic vein region and in the skin
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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