All Phenotypes Hm<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hm⁺
wild type
MGI:2431028

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hm/Hm⁺	C3Fe.Cg-Hm	MGI:3711053
cx2	Hm/Hm⁺ Rr29^Hx/Rr29⁺	C3Fe.Cg-Hm +/+ Rr29^Hx	MGI:3711061
cx3	Hm/Del(5D5Mit73-D5Mit351)5Jcs	involves: 129S4/SvJae * C57BL/6J	MGI:3027472

Allelic Composition	Hm/Hm⁺
Genetic Background	C3Fe.Cg-Hm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hm mutation (3 available); any Hm mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

abnormal phalanx morphology ( J:13425 , J:43743 )

• on all four feet, the second phalanx of digits 2,3,4,and 5 is strongly flexed (J:13425)

• detectable by E15 (J:43743)

interdigital webbing ( J:68687 )

• partial webbing

• webbing prevents toe elongation, resulting in flexion at birth

skeleton

abnormal phalanx morphology ( J:13425 , J:43743 )

• on all four feet, the second phalanx of digits 2,3,4,and 5 is strongly flexed (J:13425)

• detectable by E15 (J:43743)

Allelic Composition	Hm/Hm⁺ Rr29^Hx/Rr29⁺
Genetic Background	C3Fe.Cg-Hm +/+ Rr29^Hx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hm mutation (3 available); any Hm mutation (3 available)
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

polydactyly ( J:68687 )

• preaxial polydactyly with normal tibia

syndactyly ( J:68687 )

• syndactyly is more severe than seen in single heterozygous Hm mutants

interdigital webbing ( J:68687 )

• complete webbing of all hind feet digits that extend to the tip of the distal phalanges

Allelic Composition	Hm/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available); any Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available)
Hm mutation (3 available); any Hm mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

interdigital webbing ( J:63451 )

• retention of skin between digits giving the appearance of webbing

• this phenotype is identical to Hm heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13