immune system
• the number of IgM plaque forming cells in the bone marrow and spleen are reduced
• following LPS-induced proliferation of spleen cells, the number of IgM plaque forming cells is reduced but overall proliferation is similar to wild-type
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• inefficient activation of complement by serum IgM
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• accumulation of Ig is seen in LPS-stimulated spleen cells suggesting a defect in assembly or secretion of Ig
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• IgA and IgM levels are decreased in gut lavage compared to wild-type mice
• oral immunization with cholera toxin-induced gut lavage levels of IgA are reduced compared to wild-type but higher than in homozygotes
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• at 12 weeks of age, but serum IgA levels are similar to wild-type
(J:49168)
• high molecular mass IgM is absent from the serum indicating absence of the pentameric form of IgM that is found in wild-type mice
(J:49168)
|
• mice orally immunized with cholera toxin display reduced gut antitoxic protection compared to immunized wild-type mice but are more protected than immunized homozygotes
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hematopoietic system
• the number of IgM plaque forming cells in the bone marrow and spleen are reduced
• following LPS-induced proliferation of spleen cells, the number of IgM plaque forming cells is reduced but overall proliferation is similar to wild-type
|
• IgA and IgM levels are decreased in gut lavage compared to wild-type mice
• oral immunization with cholera toxin-induced gut lavage levels of IgA are reduced compared to wild-type but higher than in homozygotes
|
• at 12 weeks of age, but serum IgA levels are similar to wild-type
(J:49168)
• high molecular mass IgM is absent from the serum indicating absence of the pentameric form of IgM that is found in wild-type mice
(J:49168)
|