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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgal+
wild type
MGI:2431255
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Itgaltm1Mak/Itgal+ B6.129P2-Itgaltm1Mak MGI:3722099
ht2
 		Itgaltm1Bll/Itgal+ involves: 129S7/SvEvBrd MGI:6367662


Genotype
MGI:3722099
ht1
Allelic
Composition		 Itgaltm1Mak/Itgal+
Genetic
Background		 B6.129P2-Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Mak mutation (2 available); any Itgal mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to endotoxin shock ( J:123460 )
• following treatment with a lethal dose of LPS, mice succumb after 10 hours compared to wild-type mice that succumb after 8 hours
• mice exhibit a delay in the onset of liver injury in response to low doses of LPS with injury levels at 8 hours comparable to those seen at 6 hours in wild-type mice




Genotype
MGI:6367662
ht2
Allelic
Composition		 Itgaltm1Bll/Itgal+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:267548 )
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:267548 )
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory