All Phenotypes Oprm1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oprm1⁺
wild type
MGI:2431538

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Oprm1^tm1Jep/Oprm1⁺	B6.129S-Oprm1^tm1Jep	MGI:4358702
ht2	Oprm1^tm1Uhl/Oprm1⁺	either: B6.129S7-Oprm1^tm1Uhl or (involves: 129S7/SvEvBrd)	MGI:3623099
ht3	Oprm1^tm1Loh/Oprm1⁺	involves: 129P2/OlaHsd	MGI:3625879
ht4	Oprm1^tm1Jep/Oprm1⁺	involves: 129S/SvEv	MGI:4358622
ht5	Oprm1^tm1Lyu/Oprm1⁺	involves: Black Swiss	MGI:3845909
cx6	Oprm1^tm1Kff/Oprm1⁺ Tg(MECP2)1Hzo/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5314413

Allelic Composition	Oprm1^tm1Jep/Oprm1⁺
Genetic Background	B6.129S-Oprm1^tm1Jep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

abnormal operant conditioning behavior ( J:101294 )

• during the 3 hours feeding period, mice exhibit a lower decrease running wheel activity compared with similarly treated wild-type mice

induced hyperactivity ( J:101294 )

• following treatment with amphetamine, mice exhibit a greater increase in locomotor activity compared with similarly treated wild-type mice

Allelic Composition	Oprm1^tm1Uhl/Oprm1⁺
Genetic Background	either: B6.129S7-Oprm1^tm1Uhl or (involves: 129S7/SvEvBrd)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Uhl mutation (1 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:106256 )

• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type

behavior/neurological

enhanced conditioned place preference behavior ( J:106256 )

• heterozygous mice on the mixed background show almost double the preference for compartments paired with 5 or 10 mg/kg morphine compared to wild-type

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:106256 )

• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type

decreased physiological sensitivity to xenobiotic ( J:106256 )

• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type

Allelic Composition	Oprm1^tm1Loh/Oprm1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Loh mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:47187 )

• the LD50 of morphine in heterozygotes is 800 mg/kg, compared to 400 mg/kg for wild-type

behavior/neurological

decreased chemically-elicited antinociception ( J:47187 )

• ED50 of morphine in wild-type is 3.67 mg/kg and 4.49 mg/kg in heterozygotes

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:47187 )

• the LD50 of morphine in heterozygotes is 800 mg/kg, compared to 400 mg/kg for wild-type

Allelic Composition	Oprm1^tm1Jep/Oprm1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:52952 , J:65217 )

• in a tail flick assay, mice exhibit an intermediate analgesic response following morphine, methadone, or DAMGO treatment compared with wild-type and homozygous mice (J:52952)

• however, analgesic response to U50,488H, naloxone benzoylhydrazone (NalBzoH), morphine-6beta-glucuronide (M6G), heroine, 6-acetyl-morphine, and D-Penicillamine(2,5)-enkephalin (DPDPE) is normal (J:52952)

• morphine analgesic response is attenuated compared to in wild-type mice (J:65217)

enhanced behavioral response to anesthetic ( J:65217 )

• improgan analgesic response is enhanced in female mice compared to in wild-type mice

• however, improgan analgesia in males is normal

impaired behavioral response to anesthetic ( J:52952 , J:65217 )

• in a tail flick assay, mice exhibit an intermediate analgesic response following morphine, methadone, or DAMGO treatment compared with wild-type and homozygous mice (J:52952)

• morphine analgesic response is attenuated compared to in wild-type mice (J:65217)

Allelic Composition	Oprm1^tm1Lyu/Oprm1⁺
Genetic Background	involves: Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Lyu mutation (0 available); any Oprm1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:39864 )

• morphine fails to induce increased horizontal activity levels or reduced vertical activity levels

increased vertical activity ( J:39864 )

• morphine fails to induced reduced vertical activity levels unlike in wild-type mice

• however, untreated vertical activity levels are similar to wild-type controls

decreased locomotor activity ( J:39864 )

• reduced spontaneous locomotor activity compared to wild-type controls but activity levels are higher than in homozygous null mice

• morphine fails to induced increased activity levels

reduced male mating frequency ( J:39864 )

• in a 2 hr test males fail to produce seminal plugs however, males can produce seminal plugs when left overnight with a female

hematopoietic system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

abnormal bone marrow cell physiology ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the femoral bone marrow

immune system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

cellular

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

Allelic Composition	Oprm1^tm1Kff/Oprm1⁺ Tg(MECP2)1Hzo/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Kff mutation (1 available); any Oprm1 mutation (53 available)
Tg(MECP2)1Hzo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:181213 )

• double mutants exhibit a similar level of anxiety-like behavior in the elevated plus maze and light/dark box as single Tg(MECP2)1Hzo hemizygous mice

• however, double mutants exhibit improved social behavior deficits compared to single Tg(MECP2)1Hzo mice, spending more time investigating both familiar and novel partners

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