All Phenotypes Src<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Src⁺
wild type
MGI:2431997

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Src^{tm2a(EUCOMM)Wtsi}/Src⁺	B6JTyr;B6N-Src^{tm2a(EUCOMM)Wtsi}/Wtsi	MGI:5781765
cn2	Src^tm1Mul/Src⁺ Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5314777
cx3	Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src⁺	involves: 129S7/SvEvBrd	MGI:3574822

Allelic Composition	Src^{tm2a(EUCOMM)Wtsi}/Src⁺
Genetic Background	B6JTyr;B6N-Src^{tm2a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0058_2_D10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Src^{tm2a(EUCOMM)Wtsi} mutation (1 available); any Src mutation (144 available)

Data Sources

IMPC Data for Src

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

limbs/digits/tail

abnormal femur morphology ( J:175295 )

IMPC - WTSI

skeleton

abnormal femur morphology ( J:175295 )

IMPC - WTSI

Allelic Composition	Src^tm1Mul/Src⁺ Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Src^tm1Mul mutation (0 available); any Src mutation (144 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Analysis of tumorigenesis

neoplasm

increased mammary gland tumor incidence ( J:181822 )

• with later onset than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:181822 )

• with later onset than in Tg(MMTV-PyVT)#Mul mice

integument

increased mammary gland tumor incidence ( J:181822 )

• with later onset than in Tg(MMTV-PyVT)#Mul mice

Allelic Composition	Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyn^tm1Sor mutation (3 available); any Fyn mutation (37 available)
Src^tm1Sor mutation (2 available); any Src mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nursing ( J:20346 )

• difficulty in nursing newborn pups on the occasional cases where females became pregnant

reproductive system

reduced female fertility ( J:20346 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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