All Phenotypes Tgfb3<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tgfb3⁺
wild type
MGI:2432214

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tgfb3^{tm1.1(KOMP)Vlcg}/Tgfb3⁺	C57BL/6N-Tgfb3^{tm1.1(KOMP)Vlcg}/Tcp	MGI:5797862
ht2	Tgfb3^tm1Doe/Tgfb3⁺	involves: 129P2/OlaHsd	MGI:5008271
cx3	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3⁺	involves: 129 * BALB/c * C57BL/6J * Swiss Webster	MGI:5008410
cx4	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3⁺	involves: 129 * C57BL/6J * ICR * Swiss Webster	MGI:5008413
cx5	Tgfb2^tm1Doe/Tgfb2⁺ Tgfb3^tm1Doe/Tgfb3⁺	involves: 129P2/OlaHsd	MGI:5008269
cx6	Tgfb2^tm1Doe/Tgfb2^tm1Doe Tgfb3^tm1Doe/Tgfb3⁺	involves: 129P2/OlaHsd	MGI:5008267
cx7	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster	MGI:5008408

Allelic Composition	Tgfb3^{tm1.1(KOMP)Vlcg}/Tgfb3⁺
Genetic Background	C57BL/6N-Tgfb3^{tm1.1(KOMP)Vlcg}/Tcp
Cell Lines	17043A-C4

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb3^{tm1.1(KOMP)Vlcg} mutation (2 available); any Tgfb3 mutation (34 available)

Data Sources

IMPC Data for Tgfb3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

IMPC - TCP

immune system

enlarged lymph nodes ( J:211773 )

IMPC - TCP

reproductive system

abnormal testis morphology ( J:211773 )

IMPC - TCP

Allelic Composition	Tgfb3^tm1Doe/Tgfb3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb3^tm1Doe mutation (1 available); any Tgfb3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased enterocyte apoptosis ( J:76342 )

• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice

• however, enterocyte apoptosis in the colon is normal

abnormal small intestinal villus morphology ( J:76342 )

• villus length is increased compared to in wild-type mice

cellular

decreased enterocyte apoptosis ( J:76342 )

• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice

• however, enterocyte apoptosis in the colon is normal

Allelic Composition	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb1^tm1Jmu mutation (0 available); any Tgfb1 mutation (34 available)
Tgfb3^tm1Doe mutation (1 available); any Tgfb3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:136106 )

• most mice only survive 3 weeks before dying of widespread inflammation

cardiovascular system

intracranial hemorrhage ( J:136106 )

• rarely

nervous system

intracranial hemorrhage ( J:136106 )

• rarely

Allelic Composition	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3⁺
Genetic Background	involves: 129 * C57BL/6J * ICR * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:136106 )

• most mice only survive 3 weeks before dying of widespread inflammation

cardiovascular system

abnormal brain vasculature morphology ( J:136106 )

• in newborn mice, brain vasculature exhibits cavitation compared to in control mice

intracranial hemorrhage ( J:136106 )

• in all newborn mice

• less severe than in double homozygotes

nervous system

abnormal brain vasculature morphology ( J:136106 )

• in newborn mice, brain vasculature exhibits cavitation compared to in control mice

intracranial hemorrhage ( J:136106 )

• in all newborn mice

• less severe than in double homozygotes

hydrocephaly ( J:136106 )

• in newborn mice

Allelic Composition	Tgfb2^tm1Doe/Tgfb2⁺ Tgfb3^tm1Doe/Tgfb3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2^tm1Doe mutation (2 available); any Tgfb2 mutation (34 available)
Tgfb3^tm1Doe mutation (1 available); any Tgfb3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased enterocyte apoptosis ( J:76342 )

• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice

• however, enterocyte apoptosis in the colon is normal

abnormal small intestinal villus morphology ( J:76342 )

• villus length is increased compared to in wild-type mice

cellular

decreased enterocyte apoptosis ( J:76342 )

• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice

• however, enterocyte apoptosis in the colon is normal

Allelic Composition	Tgfb2^tm1Doe/Tgfb2^tm1Doe Tgfb3^tm1Doe/Tgfb3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina apoptosis ( J:105113 )

• retinal cell death is reduced compared to in wild-type mice

abnormal cornea morphology ( J:105113 )

• with detached areas

decreased cornea stroma thickness ( J:105113 )

abnormal eye posterior chamber morphology ( J:105113 )

• mice exhibit vascularized accumulation of cells in the posterior chamber of the eye unlike in wild-type mice

abnormal lens epithelium morphology ( J:105113 )

• lens epithelium thickness is decreased compared to in wild-type mice

abnormal retina neuronal layer morphology ( J:105113 )

• mice exhibit thickened neural retina compared with wild-type mice

• the neural retina is consistently detached from the pigment epithelium unlike in wild-type mice

• however, the outer retina and optic fiber layers are of normal thickness

abnormal retina inner nuclear layer morphology ( J:105113 )

• thickened

limbs/digits/tail

abnormal interdigital cell death ( J:76541 )

• at E13.5, mice exhibit decreased apoptosis in the interdigital zone compared to in wild-type mice

interdigital webbing ( J:76541 )

• at E15.5

skeleton

abnormal cartilage development ( J:76541 )

• at E15.5, chondrogenesis in the digits is accelerated compared to in wild-type mice

cellular

abnormal interdigital cell death ( J:76541 )

• at E13.5, mice exhibit decreased apoptosis in the interdigital zone compared to in wild-type mice

decreased retina apoptosis ( J:105113 )

• retinal cell death is reduced compared to in wild-type mice

Allelic Composition	Tgfb1^tm1Jmu/Tgfb1^tm1Jmu Tgfb3^tm1Doe/Tgfb3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:136106 )

• most mice only survive 3 weeks before dying of widespread inflammation

embryonic lethality during organogenesis, incomplete penetrance ( J:136106 )

• most mice die between E8.5 and E12.5

cardiovascular system

absent vitelline blood vessels ( J:136106 )

• in non-viable mice

intracranial hemorrhage ( J:136106 )

• rarely

embryo

absent vitelline blood vessels ( J:136106 )

• in non-viable mice

nervous system

intracranial hemorrhage ( J:136106 )

• rarely

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