All Phenotypes Xist<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Xist⁺
wild type
MGI:2432398

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Xist^tm2.1Jae/Xist⁺	involves: 129	MGI:3719989
ht2	Xist^tm1.1Nbd/Xist⁺	involves: 129 * C57BL/6	MGI:3718212
ht3	Xist^tm4.1Nbd/Xist⁺	involves: 129P2/OlaHsd	MGI:3640296
ht4	Xist^tm5.2Nbd/Xist⁺	involves: 129P2/OlaHsd	MGI:4950465
ht5	Rps12-ps1/Xist^tm1Nbd/Xist⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3718214
ht6	Xist^tm3Nbd/Xist⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3718209
ht7	Xist^tm2.1Nbd/Xist⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3718210
ht8	Xist^tm2Nbd/Xist⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3718211
ht9	Rps12-ps1/Xist^tm1.1Nbd/Xist⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3718217
ht10	Tsix/Xist^tm3Sado/Xist⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3772878
ht11	Xist^tm4Sado/Xist⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3772879
ht12	Xist^tm2Sado/Xist⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3716330
ht13	Xist^tm5Sado/Xist⁺	involves: 129S4/SvJae	MGI:3829657
ht14	Xist^tm1Jae/Xist⁺	involves: 129S4/SvJae	MGI:3719988
cx15	Tg(CAG-EGFP)D4Nagy/0 Xist^tm5.2Nbd/Xist⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:4950463
cx16	Tsix^tm1Enl/Tsix⁺ Xist^tm1Sado/Xist⁺	involves: 129S4/SvJae	MGI:3603005
cx17	Tsix^tm1Enl/Tsix⁺ Xist^tm1Jae/Xist⁺	involves: 129S4/SvJae	MGI:2680291

Allelic Composition	Xist^tm2.1Jae/Xist⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm2.1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:95871 )

• E7.0 embryos exhibit selective inactivation of the wild-type allele instead of the random inactivation observed in wild-type embryos

embryo

embryonic growth retardation ( J:174672 )

• when the allele is inherited paternally, female mice exhibit severe developmental defect at E7.5 compared with control mice

growth/size/body

embryonic growth retardation ( J:174672 )

• when the allele is inherited paternally, female mice exhibit severe developmental defect at E7.5 compared with control mice

Allelic Composition	Xist^tm1.1Nbd/Xist⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm1.1Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:85305 )

N	• X inactivation is normal

Allelic Composition	Xist^tm4.1Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm4.1Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:109502 )

Allelic Composition	Xist^tm5.2Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm5.2Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171502 )

• when the allele is paternally inherited, female mice die by E10.5

embryo

embryonic growth retardation ( J:171502 )

• at E7.5 in female embryos when the allele is paternally inherited

decreased embryo size ( J:171502 )

• at E8.5 and E9.5 in female embryos when the allele is paternally inherited

open neural tube ( J:171502 )

• when the allele is paternally inherited, E9.5 female mice exhibit incomplete caudal fusion unlike wild-type mice

absent placental labyrinth ( J:171502 )

• when the allele is paternally inherited, female mice fail to develop a placenta unlike wild-type male mice

growth/size/body

embryonic growth retardation ( J:171502 )

• at E7.5 in female embryos when the allele is paternally inherited

decreased embryo size ( J:171502 )

• at E8.5 and E9.5 in female embryos when the allele is paternally inherited

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:171502 )

• when the allele is paternally inherited, female mice fail to exhibit X-linked gene silencing compared with wild-type mice

nervous system

open neural tube ( J:171502 )

• when the allele is paternally inherited, E9.5 female mice exhibit incomplete caudal fusion unlike wild-type mice

Allelic Composition	Rps12-ps1/Xist^tm1Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps12-ps1/Xist^tm1Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:85305 )

N	• X inactivation is normal

Allelic Composition	Xist^tm3Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm3Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:85305 )

• mice exhibit non-random X inactivation

Allelic Composition	Xist^tm2.1Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm2.1Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:85305 )

• mice exhibit non-random X inactivation to a less extent than Xist^tm2Nbd heterozygotes

Allelic Composition	Xist^tm2Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm2Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:85305 )

• mice exhibit non-random X inactivation to a less extent than Xist^tm2Nbd heterozygotes

Allelic Composition	Rps12-ps1/Xist^tm1.1Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps12-ps1/Xist^tm1.1Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:85305 )

N	• X inactivation status was not determined

Allelic Composition	Tsix/Xist^tm3Sado/Xist⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix/Xist^tm3Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:130425 )

• when this allele is inherited paternally no XX female offsprings are observed 3 weeks after birth and only 1 XO female is produced although sex ratios are normal at E7.5

embryo

abnormal embryo development ( J:130425 )

• authors state that when this allele is inherited maternally, mice exhibit phenotypes associated with a failure of imprinted X-inactivation as in Xist^tm1Jae Tsix^tm1Enl heterozygotes

cellular

abnormal DNA methylation ( J:130425 )

• methylation at the Xist promoter is lost and histone modifications at the promoter are aberrant

Allelic Composition	Xist^tm4Sado/Xist⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm4Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:130425 )

• when inherited paternally this allele is embryonic lethal

Allelic Composition	Xist^tm2Sado/Xist⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm2Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:99399 )

N	• DNA methylation patterns are normal

Allelic Composition	Xist^tm5Sado/Xist⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm5Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:142921 )

• when this allele is inherited paternally, only 2 XO females were born

• however, birth rates are normal when this allele is inherited maternally

embryo

abnormal embryo development ( J:142921 )

• when this allele is inherited paternally, female mice exhibit an abnormal morphology at E6.5

decreased embryo size ( J:142921 )

• when this allele is inherited paternally, mice are stunted at E6.5

abnormal extraembryonic ectoderm morphology ( J:142921 )

• when this allele is inherited paternally, female mice exhibit abnormal extraembryonic ectoderm at E6.5

cellular

abnormal imprinting ( J:142921 )

• when this allele is inherited paternally

growth/size/body

decreased embryo size ( J:142921 )

• when this allele is inherited paternally, mice are stunted at E6.5

Allelic Composition	Xist^tm1Jae/Xist⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xist^tm1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:95871 )

• E7.0 embryos exhibit selective inactivation of the wild-type allele instead of the random inactivation observed in wild-type embryos

Allelic Composition	Tg(CAG-EGFP)D4Nagy/0 Xist^tm5.2Nbd/Xist⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Xist^tm5.2Nbd mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:171502 )

• when the allele is maternally inherited, mice exhibit secondary non-random X inactivation compared with wild-type mice

Allelic Composition	Tsix^tm1Enl/Tsix⁺ Xist^tm1Sado/Xist⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix^tm1Enl mutation (1 available); any Tsix mutation (57 available)
Xist^tm1Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:99399 )

• females that have both mutations on the paternal X chromosome die soon after implantation; however, females that have both mutations on the maternal X chromosome are viable and fertile

Allelic Composition	Tsix^tm1Enl/Tsix⁺ Xist^tm1Jae/Xist⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix^tm1Enl mutation (1 available); any Tsix mutation (57 available)
Xist^tm1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:68136 )

• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5

• gastrulation was apparently normal however

• remaining embryos were grossly normal in size and morphology

growth/size/body

decreased embryo size ( J:68136 )

• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5

• gastrulation was apparently normal however

• remaining embryos were grossly normal in size and morphology

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