All Phenotypes Clock<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Clock⁺
wild type
MGI:2432679

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Clock^m1Jt/Clock⁺	B6(C)-Clock^m1Jt	MGI:5515434
ht2	Clock^m1Jt/Clock⁺	C57BL/6-Clock^m1Jt	MGI:2663350
ht3	Clock^m1Jt/Clock⁺	involves: C57BL/6	MGI:4822130
cx4	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1⁺	(BALB/cJ x C57BL/6J)F1	MGI:5515432
cx5	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1^soc	C.B6-Clock^m1Jt	MGI:5515721
cx6	Clock^m1Jt/Clock⁺ Per2^tm1Jt/Per2⁺ Usf1^soc/?	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J	MGI:5515433
cx7	Clock^m1Jt/Clock⁺ Tg(CMV-Usf1)1Jt/0	involves: C57BL/6J	MGI:5515431

Allelic Composition	Clock^m1Jt/Clock⁺
Genetic Background	B6(C)-Clock^m1Jt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:198519 )

• Background Sensitivity: under constant darkness, mice on a C57BL/6 congenic background exhibit prolonged activity periods compared with mice on a congenic BALB/cJ background

Allelic Composition	Clock^m1Jt/Clock⁺
Genetic Background	C57BL/6-Clock^m1Jt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:101849 )

• in a forced-swim test, female mice exhibit less immobility compared with wild-type mice but as much as in Clock^m1Jt homozygotes

• however, anxiety and depressive-like behavior are not increased

increased exploration in new environment ( J:101849 )

• during constant darkness in an open field, mice spend more time exploring the center than wild-type mice but as much as in Clock^m1Jt homozygotes

increased vertical activity ( J:101849 )

• in female mice in an open field test

prolonged circadian behavior period ( J:18005 , J:198519 )

• circadian period gradually lengthens over the first 39 days of constant darkness, with an average of 24.4 hours compared to 23.2 hours in wild-type (J:18005)

• increased 0.6 hr upon exposure to constant darkness (J:198519)

• Background Sensitivity: mice on a C57BL/6J isogenic background exhibit a longer activity period under constant darkness than mice on a (BALB/cJ x C57BL/6J)F1 or BALB/cJ congenic background (J:198519)

abnormal circadian behavior phase ( J:98343 )

• in constant darkness, mice exhibit a 1 hour increase in free-running rhythm of locomotor activity compared with wild-type mice

abnormal sleep duration ( J:65198 )

• mice spend 9% less time asleep during the entire 24 hour light dark cycle compared with wild-type mice

abnormal sleep pattern ( J:65198 )

• during the 12 hour dark phase, mice spend less time in non-REM sleep than wild-type mice

• during the 12 hour dark phase, REM sleep is shorter than in wild-type mice

Allelic Composition	Clock^m1Jt/Clock⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:155089 )

• mice exhibit decreased plasminogen activator inhibitor-1 (PAI-1) levels compared with wild-type mice

• at zeitgeber time (ZT) 14, mice fail to exhibit a decreased in total plasma tissue plasminogen activator (tPA) levels compared with wild-type mice

abnormal response to injury ( J:155089 )

• diurnal variations in time to thrombotic vascular occlusion (TTVO) subsequent to photochemical injury observed in similarly treated wild-type mice

• TTVO subsequent to photochemical injury is increased at zeitgeber time (ZT) 14 compared with similarly treated wild-type mice

Allelic Composition	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1⁺
Genetic Background	(BALB/cJ x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (102 available)
Usf1^soc mutation (0 available); any Usf1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:198519 )

• increased 0.3 hr upon exposure to constant darkness

• Background Sensitivity: mice on a (BALB/cJ x C57BL/6J)F1 background exhibit a shorted extension of activity period upon exposure to constant darkness compared with mice on a C57BL/6J congenic background

Allelic Composition	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1^soc
Genetic Background	C.B6-Clock^m1Jt

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:198519 )

N	• mice on a BALB/cJ congenic background exhibit normal activity period under constant darkness unlike mice on a C57BL/6J isogenic background

Allelic Composition	Clock^m1Jt/Clock⁺ Per2^tm1Jt/Per2⁺ Usf1^soc/?
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (102 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (71 available)
Usf1^soc mutation (0 available); any Usf1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:198519 )

• Background Sensitivity: shorter period compared to in mice on a background with more C57BL/6 contribution

Allelic Composition	Clock^m1Jt/Clock⁺ Tg(CMV-Usf1)1Jt/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (102 available)
Tg(CMV-Usf1)1Jt mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:198519 )

• shorter period compared to Clock^m1Jt heterozygotes

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