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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc1a2+
wild type
MGI:2432850
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Slc1a2tm1Kta/Slc1a2+ involves: 129P2/OlaHsd * C57BL/6 MGI:4838971
cx2
 		Slc1a2tm1Kta/Slc1a2+
Tg(SOD1*G93A)1Gur/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL/J MGI:4838970


Genotype
MGI:4838971
ht1
Allelic
Composition		 Slc1a2tm1Kta/Slc1a2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a2tm1Kta mutation (0 available); any Slc1a2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:144898 )
• only have 65% glutamate transport when compared with wild-type mice in lumbar spinal cord and cerebral cortex




Genotype
MGI:4838970
cx2
Allelic
Composition		 Slc1a2tm1Kta/Slc1a2+
Tg(SOD1*G93A)1Gur/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a2tm1Kta mutation (0 available); any Slc1a2 mutation (40 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144898 )
• shortened lifespan (137 1.7 vs. 142 1.4 days)

cellular
abnormal cell physiology ( J:144898 )
• reduced glutamate transport in lumbar spinal cord at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice

nervous system
decreased motor neuron number ( J:144898 )
• increase in the rate of motor decline accompanied by earlier motor neuron loss
• accelerated motor neuron loss at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice
• significant declines occur between 105 and 120 days (42% reduction) and between 120 days and end stage, compared with between 120 days and endstage (56%) in Tg(SOD1*G93A)1Gur mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory