Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama5tm1b(KOMP)Wtsi mutation
(0 available);
any
Lama5 mutation
(153 available)
|
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Data Sources
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cardiovascular system
![](https://www.informatics.jax.org/assets/images/Venus_symbol.svg) |
IMPC - HAR
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growth/size/body
![](https://www.informatics.jax.org/assets/images/Venus_symbol.svg) |
IMPC - HAR
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Allelic Composition |
Lama5tm1Jhm/Lama5+
|
|
Genetic Background |
involves: 129S1/Sv * 129X1/SvJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama5tm1Jhm mutation
(0 available);
any
Lama5 mutation
(153 available)
|
|
|
craniofacial
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
|
growth/size/body
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
|
skeleton
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
|
Allelic Composition |
Lama5Gt1Jhm/Lama5+
|
|
Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama5Gt1Jhm mutation
(0 available);
any
Lama5 mutation
(153 available)
|
|
|
craniofacial
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
|
growth/size/body
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
|
skeleton
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
|