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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rgs4+
wild type
MGI:2434199
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Relnctrdel/Relnctrdel
Rgs4tm1Dgen/Rgs4+ 		involves: 129P2/OlaHsd * A/J * C57BL/6 MGI:5505413
cx2
 		m2Bei/m2Bei
Rgs4tm1Dgen/Rgs4+ 		involves: 129P2/OlaHsd * A/J * C57BL/6 MGI:5505419
cx3
 		m3Bei/m3Bei
Rgs4tm1Dgen/Rgs4+ 		involves: 129P2/OlaHsd * A/J * C57BL/6 MGI:5505435
cx4
 		Dnaaf1m4Bei/Dnaaf1m4Bei
Rgs4tm1Dgen/Rgs4+ 		involves: 129P2/OlaHsd * A/J * C57BL/6 MGI:5505452
cx5
 		m5Bei/m5Bei
Rgs4tm1Dgen/Rgs4+ 		involves: 129P2/OlaHsd * A/J * C57BL/6 MGI:5505453
cx6
 		Drc3m6Bei/Drc3m6Bei
Rgs4tm1Dgen/Rgs4+ 		involves: 129P2/OlaHsd * A/J * C57BL/6 MGI:5505455


Genotype
MGI:5505413
cx1
Allelic
Composition		 Relnctrdel/Relnctrdel
Rgs4tm1Dgen/Rgs4+
Genetic
Background		 involves: 129P2/OlaHsd * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnctrdel mutation (0 available); any Reln mutation (209 available)
Rgs4tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:199782 )
N
• no cerebellar defects
abnormal stratification in cerebral cortex ( J:199782 )
• layers II, II, IV, V cannot be distinguished
• brains are otherwise normal




Genotype
MGI:5505419
cx2
Allelic
Composition		 m2Bei/m2Bei
Rgs4tm1Dgen/Rgs4+
Genetic
Background		 involves: 129P2/OlaHsd * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m2Bei mutation (0 available); any m2Bei mutation (0 available)
Rgs4tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal stratification in cerebral cortex ( J:199782 )
• superficial layers are thinner




Genotype
MGI:5505435
cx3
Allelic
Composition		 m3Bei/m3Bei
Rgs4tm1Dgen/Rgs4+
Genetic
Background		 involves: 129P2/OlaHsd * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m3Bei mutation (0 available); any m3Bei mutation (0 available)
Rgs4tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enlarged lateral ventricles ( J:199782 )
• ventriculomegaly
abnormal cerebral cortex morphology ( J:199782 )
• anterior cortex is sometimes narrow
abnormal stratification in cerebral cortex ( J:199782 )
• superficial layers are thinner
• layers II, III, IV are disturbed




Genotype
MGI:5505452
cx4
Allelic
Composition		 Dnaaf1m4Bei/Dnaaf1m4Bei
Rgs4tm1Dgen/Rgs4+
Genetic
Background		 involves: 129P2/OlaHsd * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaaf1m4Bei mutation (1 available); any Dnaaf1 mutation (32 available)
Rgs4tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:199782 )
• postnatal lethality in the third week sometimes

nervous system
enlarged lateral ventricles ( J:199782 )
• ventriculomegaly
abnormal hippocampus morphology ( J:199782 )
• posteriorly displaced
thin cerebral cortex ( J:199782 )
• severe cortical thinning

craniofacial
domed cranium ( J:199782 )
• domed heads sometimes

skeleton
domed cranium ( J:199782 )
• domed heads sometimes




Genotype
MGI:5505453
cx5
Allelic
Composition		 m5Bei/m5Bei
Rgs4tm1Dgen/Rgs4+
Genetic
Background		 involves: 129P2/OlaHsd * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
m5Bei mutation (0 available); any m5Bei mutation (0 available)
Rgs4tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:199782 )
• postnatal lethality in the third week sometimes

nervous system
enlarged lateral ventricles ( J:199782 )
• ventriculomegaly
abnormal hippocampus morphology ( J:199782 )
• small
• posteriorly displaced
thin cerebral cortex ( J:199782 )
• severe cortical thinning

craniofacial
domed cranium ( J:199782 )
• domed heads sometimes

skeleton
domed cranium ( J:199782 )
• domed heads sometimes




Genotype
MGI:5505455
cx6
Allelic
Composition		 Drc3m6Bei/Drc3m6Bei
Rgs4tm1Dgen/Rgs4+
Genetic
Background		 involves: 129P2/OlaHsd * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drc3m6Bei mutation (1 available); any Drc3 mutation (25 available)
Rgs4tm1Dgen mutation (1 available); any Rgs4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:199782 )
• postnatal lethality in the third week sometimes

nervous system
enlarged lateral ventricles ( J:199782 )
• ventriculomegaly
abnormal hippocampus morphology ( J:199782 )
• posteriorly displaced
thin cerebral cortex ( J:199782 )
• severe cortical thinning

craniofacial
domed cranium ( J:199782 )
• domed heads sometimes

skeleton
domed cranium ( J:199782 )
• domed heads sometimes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory