Analysis Tools
cardiovascular system
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• heterozygous mutant mice also displayed a modest medial expansion of renal arterioles, in the absence of cardiac hypertrophy
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• at least in anesthetized mice, equivalent and marked levels of blood pressure elevation were observed in both heterozygous and homozygous mutant mice; anesthetized heterozygous mutants were strongly hypertensive with a mean aortic blood pressure of 134 3 mmHg
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renal/urinary system
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• heterozygous mutant mice also displayed a modest medial expansion of renal arterioles, in the absence of cardiac hypertrophy
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nervous system
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• hippocampal CA1 neurons of heterozygous mutant mice showed no decrease in the density of apical and basilar spines relative to wild-type littermates
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