Phenotypes associated with this allele

• Allele Symbol: Phb2⁺
• Allele Name: wild type
• Allele ID: MGI:2435224
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Phb2^tm1Katz/Phb2^+	129S6/SvEvTac-Bcap37^tm1Katz	MGI:3574580
ht2	Phb2^tm1Katz/Phb2^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3574577
cn3	Phb2^tm2.1Katz/Phb2^+ Pgr^tm2(cre)Lyd/Pgr^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5299191
cn4	Phb2^tm2.1Katz/Phb2^+ Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5299192

Genotype
MGI:3574580

ht1

• Allelic Composition: Phb2^tm1Katz/Phb2⁺
• Genetic Background: 129S6/SvEvTac-Bcap37^tm1Katz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal uterus morphology ( J:96817 )

♀ • the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation

increased uterus weight ( J:96817 )

♀ • females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight

abnormal litter size ( J:96817 )

• exhibited smaller litter sizes than on a mixed 129S6/SvEvTac and C57BL/6 background

• litter size of the second-generation mice were reduced significantly from those of the first-generation mice (4.1 vs 6.1 pups)

Genotype
MGI:3574577

ht2

• Allelic Composition: Phb2^tm1Katz/Phb2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:96817 )

• the numbers of heterozygous mutants were underrepresented among weaned pups but did not observe death after birth, indicating that some embryos may have died during a late gestational stage

growth/size/body

increased susceptibility to weight gain ( J:96817 )

• heterozygous females exhibited a greater gain in body weight from 9 weeks of age to 26 weeks of age than in wildtype, but no differences in males

reproductive system

abnormal uterus morphology ( J:96817 )

♀ • the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation

increased uterus weight ( J:96817 )

♀ • females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight

abnormal litter size ( J:96817 )

• exhibited larger litter sizes than on the 129S6/SvEvTac coisogenic background

• litter sizes of second-generation mice were reduced significantly from those of the first-generation mice (5.9 vs 7.5 pups)

Genotype
MGI:5299191

cn3

• Allelic Composition: Phb2^tm2.1Katz/Phb2⁺; Pgr^tm2(cre)Lyd/Pgr⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

endocrine/exocrine glands

abnormal mammary gland duct morphology ( J:178347 )

♀ • during puberty, mammary ductal morphogenesis is accelerated with increased ductal length compared to in control mice

♀ • the number of terminal end buds is increased compared to in control mice

integument

abnormal mammary gland duct morphology ( J:178347 )

♀ • during puberty, mammary ductal morphogenesis is accelerated with increased ductal length compared to in control mice

♀ • the number of terminal end buds is increased compared to in control mice

Genotype
MGI:5299192

cn4

• Allelic Composition: Phb2^tm2.1Katz/Phb2⁺; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

behavior/neurological

abnormal nursing ( J:178347 )

♀ • dams support increased weight gain in nursed pups compared with pups nursed by control mice

integument

abnormal milk composition ( J:178347 )

♀ • expression of milk protein genes is increased compared to in control mice

endocrine/exocrine glands

abnormal milk composition ( J:178347 )

♀ • expression of milk protein genes is increased compared to in control mice