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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fas+
wild type
MGI:2435535
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Faslpr/Fas+
Raf1tm1Bacc/Raf1tm1Bacc 		involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL MGI:3799534
cx2
 		Faslpr/Fas+
Raf1tm1Bacc/Raf1+ 		involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL MGI:3799536
cx3
 		Faslpr/Fas+
Tg(TcraTcrb)1100Mjb/? 		involves: C57BL/6 * MRL/Mp MGI:5292731


Genotype
MGI:3799534
cx1
Allelic
Composition		 Faslpr/Fas+
Raf1tm1Bacc/Raf1tm1Bacc
Genetic
Background		 involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Raf1tm1Bacc mutation (0 available); any Raf1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:135681 )
N
• introduction of a Faslpr allele onto the Raf1-null background rescues the lethality shown by the homozygous Raf1-null embryos

hematopoietic system
hematopoietic system phenotype ( J:135681 )
N
• introduction of a Faslpr allele onto the Raf1-null background rescues the anemia observed in homozygous Raf1-null embryos
abnormal erythropoiesis ( J:135681 )
• differentiation of erythroblasts is delayed, restoring differentiation to level of Raf1 heterozygotes; differentiation is slower than observed in Raf1-null cells




Genotype
MGI:3799536
cx2
Allelic
Composition		 Faslpr/Fas+
Raf1tm1Bacc/Raf1+
Genetic
Background		 involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Raf1tm1Bacc mutation (0 available); any Raf1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:135681 )
N
• differentiation of erythroblasts from double heterozygotes is indistinguishable from wild-type cells




Genotype
MGI:5292731
cx3
Allelic
Composition		 Faslpr/Fas+
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: C57BL/6 * MRL/Mp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:72817 )
N
• after administration of OVA peptide 257-264 has no affect on mortality

liver/biliary system
liver/biliary system phenotype ( J:72817 )
N
• no morphological abnormalities or increased apoptosis after administration of OVA peptide 257-264
liver inflammation ( J:72817 )
• extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264

immune system
liver inflammation ( J:72817 )
• extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory