nervous system
• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
|
• migration defects in the hippocampus are seen
|
• mutants exhibit a modest split of the pyramidal layer in area CA1 and CA3
• however, do not show an obvious cerebral cortical layering defects
|
• a mild reduction in the number of cells in the neocortex is seen with preferential loss of later migrating cells
|
cellular
• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
|
• migration defects in the hippocampus are seen
|