Phenotypes associated with this allele

• Allele Symbol: Scn11a⁺
• Allele Name: wild type
• Allele ID: MGI:2436203
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scn11a^tm1.1Ikth/Scn11a^+	involves: 129 * BALB/c * C57BL/6	MGI:5558028
ht2	Scn11a^tm1Dgen/Scn11a^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3628546
ht3	Scn11a^em1Akoi/Scn11a^+	involves: C57BL/6	MGI:6392909
ht4	Scn11a^em2Akoi/Scn11a^+	involves: C57BL/6NCrSlc	MGI:6415034
ht5	Scn11a^em3Akoi/Scn11a^+	involves: C57BL/6NCrSlc	MGI:6415036

Genotype
MGI:5558028

ht1

• Allelic Composition: Scn11a^tm1.1Ikth/Scn11a⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:206848 )

• dorsal ganglion neurons exhibit a shifted resting membrane potential indicating active channels under resting conditions compared with wild-type cell

• diminished peak current densities at depolarized voltage

• greater inward current under resting conditions

abnormal action potential ( J:206848 )

• reduced in dorsal ganglion neurons

abnormal afterhyperpolarization ( J:206848 )

• less pronounced in dorsal ganglion neurons

abnormal miniature excitatory postsynaptic currents ( J:206848 )

• less frequent

abnormal channel response ( J:206848 )

• intermediately diminished peak current densities at depolarized voltage

integument

integument phenotype ( J:206848 )

N • prior to induction of inflammation, mice exhibit normal withdrawal threshold for plantar mechanical and thermal stimulation

skin lesions ( J:206848 )

• severe, self-inflicted tissue lesions in some mice

behavior/neurological

abnormal nociception after inflammation ( J:206848 )

• after zymogen-induced inflammation, mice exhibit a smaller reduction in the withdrawal threshold, indicating less thermal and mechanical hyperalgesia, and less protective behavior compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary sensory neuropathy		DOID:0050548	OMIM:PS162400	J:206848

Genotype
MGI:3628546

ht2

• Allelic Composition: Scn11a^tm1Dgen/Scn11a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal nociception after inflammation ( J:99870 )

• after treatment with formalin, heterozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection) and thermal hyperalgesia is less prolonged after treatment with complete Freund's adjuvant

Genotype
MGI:6392909

ht3

• Allelic Composition: Scn11a^em1Akoi/Scn11a⁺
• Genetic Background: involves: C57BL/6

behavior/neurological

abnormal thermal nociception ( J:268684 )

• the number of nociceptive behaviors in the cold plate test is higher than in wild-type mice, indicating cold hypersensitivity

• however, mice exhibit normal locomotor activity at 8-9 weeks and 36-38 weeks of age

decreased thermal nociceptive threshold ( J:268684 )

• mice exhibit a shorter paw withdrawal latency in the Hargreaves test indicating thermal hypersensitivity

nervous system

abnormal nervous system electrophysiology ( J:268684 )

• dorsal root ganglion neurons from 8-9 week old mice show higher input impedance

abnormal action potential ( J:268684 )

• dorsal root ganglion neurons from 8-9 week old mice show increased firing frequency of evoked action potentials but no difference in resting membrane potential

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial episodic pain syndrome 3		DOID:0111731	OMIM:615552	J:268684

Genotype
MGI:6415034

ht4

• Allelic Composition: Scn11a^em2Akoi/Scn11a⁺
• Genetic Background: involves: C57BL/6NCrSlc

nervous system

abnormal nervous system electrophysiology ( J:268091 )

• dorsal root ganglion neurons show increased resting membrane potentials

abnormal action potential ( J:268091 )

• dorsal root ganglion neurons show increased firing frequency of the action potentials by high input-current stimulus

• the firing probability of evoked action potentials is increased in low stimulus input

• however, other action potential parameters and current threshold do not differ

Genotype
MGI:6415036

ht5

• Allelic Composition: Scn11a^em3Akoi/Scn11a⁺
• Genetic Background: involves: C57BL/6NCrSlc

nervous system

abnormal nervous system electrophysiology ( J:268091 )

• dorsal root ganglion neurons show increased resting membrane potentials

• input impedance of dorsal root ganglion neurons is higher in response to a current injection of 10 pA

abnormal action potential ( J:268091 )

• dorsal root ganglion neurons show increased firing frequency of the action potentials by high input-current stimulus

• however, other action potential parameters and current threshold do not differ in dorsal root ganglion neurons