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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnf8+
wild type
MGI:2436313
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rnf8Gt(AS0574)Wtsi/Rnf8+ involves: 129P2/OlaHsd * C57BL/6 MGI:4459435


Genotype
MGI:4459435
ht1
Allelic
Composition		 Rnf8Gt(AS0574)Wtsi/Rnf8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf8Gt(AS0574)Wtsi mutation (0 available); any Rnf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:161240 )
• only 77% of mice are viable at 465 days compared with 97% of wild-type mice
• some mice severely runted mice die prematurely without signs of tumors

immune system
abnormal class switch recombination ( J:161240 )
• class switch recombination is impaired compared to in wild-type mice but not as severely as in homozygous mice

cellular
increased cellular sensitivity to gamma-irradiation ( J:161240 )
• bone marrow cells treated with 4 Gy or 6 Gy exhibit a modest sensitivity compared with similarly treated wild-type cells

growth/size/body
decreased body size ( J:161240 )

neoplasm
neoplasm ( J:161240 )
N
• tumorigenesis is not significantly different than in wild-type mice

hematopoietic system
abnormal class switch recombination ( J:161240 )
• class switch recombination is impaired compared to in wild-type mice but not as severely as in homozygous mice




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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory