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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcm7+
wild type
MGI:2436717
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mcm7Gt(YTA285)Byg/Mcm7+ involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838136
cx2
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm6Gt(YHD248)Byg/Mcm6+
Mcm7Gt(YTA285)Byg/Mcm7+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838124
cx3
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Mcm7Gt(YTA285)Byg/Mcm7+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838137
cx4
 		Mcm4chaos3/Mcm4chaos3
Mcm7Gt(YTA285)Byg/Mcm7+ 		involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J MGI:4838117


Genotype
MGI:4838136
ht1
Allelic
Composition		 Mcm7Gt(YTA285)Byg/Mcm7+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm7Gt(YTA285)Byg mutation (0 available); any Mcm7 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838124
cx2
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm6Gt(YHD248)Byg/Mcm6+
Mcm7Gt(YTA285)Byg/Mcm7+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm6Gt(YHD248)Byg mutation (0 available); any Mcm6 mutation (37 available)
Mcm7Gt(YTA285)Byg mutation (0 available); any Mcm7 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838137
cx3
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Mcm7Gt(YTA285)Byg/Mcm7+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
Mcm6Gt(YHD248)Byg mutation (0 available); any Mcm6 mutation (37 available)
Mcm7Gt(YTA285)Byg mutation (0 available); any Mcm7 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838117
cx4
Allelic
Composition		 Mcm4chaos3/Mcm4chaos3
Mcm7Gt(YTA285)Byg/Mcm7+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4chaos3 mutation (1 available); any Mcm4 mutation (42 available)
Mcm7Gt(YTA285)Byg mutation (0 available); any Mcm7 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:165667 )
• only 8% of expected mice survive to weaning
prenatal lethality, incomplete penetrance ( J:165667 )
• 50% of expected mice are liveborn

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
reticulocytosis ( J:165667 )
• mice exhibit an increase in the number of CD71+ (proliferating cells, reticulocytes, erythroid precursors) cells compared with Mcm4chaos3 homozygotes

cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes

growth/size/body
decreased body weight ( J:165667 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory